NELFCD - negative elongation factor complex member C/D Gene

Also Known as TH1; TH1L; NELF-C; NELF-D; HSPC130

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51497

Summary

The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
Ubiquitous expression in testis (RPKM 29.3), thyroid (RPKM 23.1) and 25 other tissues.

NELFCD Products (1)

mRNA Protein Name
NM_198976.4 NP_945327.3 negative elongation factor C/D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12612062 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
12612062 GOA
Cellular Component GO Annotation Evidence References Source
part of NELF complex IDA
IDA: Inferred from direct assay
12612062 GOA
part of NELF complex IPI
IPI: Inferred from physical interaction
12612062 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12612062 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NELFCD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NELFCD Q8IXH7 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
NELFCD Q8IXH7 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
NELFCD Q8IXH7 NELFB Homo sapiens Q8WX92-2
Y2H Prey Pooling
32296183
Intra
NELFCD Q8IXH7 NELFB Homo sapiens Q8WX92-2
Y2H Array
32296183
Intra
NELFCD Q8IXH7 NELFB Homo sapiens Q8WX92-2
Validated Y2H
32296183
Intra
NELFCD Q8IXH7 ARAF Homo sapiens P10398
Y2H
12620389
Intra
NELFCD Q8IXH7 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
NELFCD Q8IXH7 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
NELFCD Q8IXH7 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
NELFCD Q8IXH7 NELFA Homo sapiens Q9H3P2
Validated Y2H
25416956
Intra
NELFCD Q8IXH7 NELFA Homo sapiens Q9H3P2
Y2H Prey Pooling
32296183
Intra
NELFCD Q8IXH7 NELFA Homo sapiens Q9H3P2
Y2H Prey Pooling
25416956
Intra
NELFCD Q8IXH7 NELFA Homo sapiens Q9H3P2
Validated Y2H
32296183
Intra
NELFCD Q8IXH7 NELFA Homo sapiens Q9H3P2
TAP
24981860
Intra
NELFCD Q8IXH7 NELFA Homo sapiens Q9H3P2
Y2H Array
32296183
Intra
NELFCD Q8IXH7 NELFA Homo sapiens Q9H3P2
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS29548 NELFCD Human Pre-designed siRNA Set A Pre-designed Set / Unkown