PPIB - peptidylprolyl isomerase B Gene

Also Known as OI9; CYPB; SCYLP; CYP-S1; HEL-S-39

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5479

About PPIB

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,155,817-64,163,022 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues, 22 paralogues and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 295.6), placenta (RPKM 241.5) and 25 other tissues.

Summary

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

PPIB Products (1)

mRNA	Protein	Name
NM_000942.5	NP_000933.1	peptidyl-prolyl cis-trans isomerase B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase binding	IPI IPI: Inferred from physical interaction	15989969	GOA
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	20676357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15095401	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bone development	IMP IMP: Inferred from mutant phenotype	20089953	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	22665516	GOA
NOT involved in chaperone-mediated protein folding	IMP IMP: Inferred from mutant phenotype	20089953	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	11688976	GOA
involved in positive regulation by host of viral genome replication	IMP IMP: Inferred from mutant phenotype	15989969	GOA
involved in positive regulation by host of viral process	IMP IMP: Inferred from mutant phenotype	15989969	GOA
involved in positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	20089953	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20089953	GOA
NOT involved in regulation of post-translational protein modification	IMP IMP: Inferred from mutant phenotype	20089953	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	20089953	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15989969	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIB Protein Structure

Pro_isomerase

0
100
200
216 a.a.

Protein Preferred Names	Protein Names
peptidyl-prolyl cis-trans isomerase B	PPIase B

PPIB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPIB	P23284	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	PPIB	P23284	PDIA4	Homo sapiens	P13667	NMR	22665516
Intra	PPIB	P23284	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32814053
Intra	PPIB	P23284	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32814053
Intra	PPIB	P23284	WWOX	Homo sapiens	Q9NZC7-5	Y2H Pooling	32814053
Intra	PPIB	P23284	CENPV	Homo sapiens	Q7Z7K6	Validated Y2H	32814053
Intra	PPIB	P23284	CENPV	Homo sapiens	Q7Z7K6	Y2H Pooling	32814053
Intra	PPIB	P23284	CENPV	Homo sapiens	Q7Z7K6	Y2H Array	32814053
Intra	PPIB	P23284	a0a087wzy1_human	Homo sapiens	A0A087WZY1	Y2H Array	32296183
Intra	PPIB	P23284	a0a087wzy1_human	Homo sapiens	A0A087WZY1	Y2H Prey Pooling	32296183
Intra	PPIB	P23284	TRDN	Homo sapiens	Q13061-2	Y2H Array	32296183
Intra	PPIB	P23284	TRDN	Homo sapiens	Q13061-2	Y2H Prey Pooling	32296183
Intra	PPIB	P23284	TRDN	Homo sapiens	Q13061-2	Validated Y2H	32296183
Intra	PPIB	P23284	LHX5	Homo sapiens	Q9H2C1	Validated Y2H	32814053
Intra	PPIB	P23284	LHX5	Homo sapiens	Q9H2C1	Y2H Array	32814053
Intra	PPIB	P23284	LHX5	Homo sapiens	Q9H2C1	Y2H Pooling	32814053
Intra	PPIB	P23284	RMND1	Homo sapiens	Q9NWS8-3	Validated Y2H	32814053
Intra	PPIB	P23284	RMND1	Homo sapiens	Q9NWS8-3	Y2H Array	32814053
Intra	PPIB	P23284	RMND1	Homo sapiens	Q9NWS8-3	Y2H Pooling	32814053
Intra	PPIB	P23284	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	PPIB	P23284	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	PPIB	P23284	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	PPIB	P23284	HSPA6	Homo sapiens	P17066	Y2H Prey Pooling	32296183
Intra	PPIB	P23284	HSPA6	Homo sapiens	P17066	Y2H Array	32296183
Intra	PPIB	P23284	STIM1	Homo sapiens	Q13586	Y2H Array	32814053
Intra	PPIB	P23284	STIM1	Homo sapiens	Q13586	Validated Y2H	32814053
Intra	PPIB	P23284	STIM1	Homo sapiens	Q13586	Y2H Pooling	32814053
Intra	PPIB	P23284	PEX19	Homo sapiens	P40855	Y2H Prey Pooling	32296183
Intra	PPIB	P23284	PEX19	Homo sapiens	P40855	Y2H Prey Pooling	25416956
Intra	PPIB	P23284	PEX19	Homo sapiens	P40855	Validated Y2H	25416956
Intra	PPIB	P23284	PEX19	Homo sapiens	P40855	Validated Y2H	32296183
Intra	PPIB	P23284	PEX19	Homo sapiens	P40855	Y2H Array	32296183
Intra	PPIB	P23284	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	25416956
Intra	PPIB	P23284	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	PPIB	P23284	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	PPIB	P23284	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	PPIB	P23284	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	PPIB	P23284	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	PPIB	P23284	BANP	Homo sapiens	Q8N9N5	Y2H Array	25416956
Intra	PPIB	P23284	KLF12	Homo sapiens	Q9Y4X4	Validated Y2H	32814053
Intra	PPIB	P23284	KLF12	Homo sapiens	Q9Y4X4	Y2H Array	32814053
Intra	PPIB	P23284	KLF12	Homo sapiens	Q9Y4X4	Y2H Pooling	32814053
Intra	PPIB	P23284	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PPIB	P23284	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PPIB	P23284	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Cross	PPIB	P23284	Q9WMX2-PRO_0000037552	Hepatitis C virus	Q9WMX2-PRO_0000037552	Anti Bait CoIP	15989969
Cross	PPIB	P23284	Q9WMX2-PRO_0000037552	Hepatitis C virus	Q9WMX2-PRO_0000037552	Pull Down	15989969

Cross: Cross-species interaction Intra: Intraspecies interaction

PPIB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80638	Cyclophilin B Antibody (YA787)	WB, IHC-P	Human, Rat, Mouse
HY-P80638A	Cyclophilin B Antibody (YA787)(PBS only)	WB, IHC-P	Human, Rat, Mouse
HY-P85744	Cyclophilin B Antibody (YA5436)	WB, IHC-P, ICC/IF	Human, Rat, Mouse

Related Diseases

Diseases	Alias
Osteogenesis Imperfecta, Type Ix	Osteogenesis Imperfecta Type 9 Osteogenesis Imperfecta Type Ix OI9 Oi Type Ix Osteogenesis Imperfecta Sillence Type Ii/Iii Without Abnormality Of Type I Collagen Oi, Type Ix Oi 9 Osteogenesis Imperfecta 9 Oi-Ix
Osteogenesis Imperfecta, Type Ii	Vrolik Type Of Osteogenesis Imperfecta Osteogenesis Imperfecta Type 2 OI2 Oi, Type Ii Osteogenesis Imperfecta Congenita Oic Osteogenesis Imperfecta Type Ii Lethal Osteogenesis Imperfecta Oi Type 2 Osteogenesis Imperfecta Congenita Perinatal Lethal Form Osteogenesis Imperfecta Congenita, Perinatal Lethal Form Perinatal Lethal Osteogenesis Imperfecta Congenita Perinatally Lethal Oi Osteogenesis Imperfecta 2 Oi-Ii Oi-Iia Oi Type Iia Osteogenesis Imperfecta Type Iia Osteogenesis Imperfecta Type Ii Autosomal Dominant Oi Type Ii Osteogenesis Imperfecta, Dominant Perinatal Lethal
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Osteogenesis Imperfecta, Type Iii	Osteogenesis Imperfecta Type Iii OI3 Oi, Type Iii Osteogenesis Imperfecta Type 3 Oi Type Iii Oi Type 3 Progressive Deforming Osteogenesis Imperfecta Severe Osteogenesis Imperfecta Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae Progressively Deforming Osteogenesis Imperfecta With Normal Sclera Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae Progressively Deforming Oi Osteogenesis Imperfecta 3 Oi-Iii Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Dentinogenesis Imperfecta	Hereditary Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi Capdepont Teeth Dgi Without Oi Di Non-Syndromic Dgi Non-Syndromic Dentinogenesis Imperfecta Opalescent Teeth Without Oi Opalescent Teeth Without Osteogenesis Imperfecta Opalescent Dentin
Osteogenesis Imperfecta, Type Vii	Osteogenesis Imperfecta Type 7 Osteogenesis Imperfecta Type Vii OI7 Oi Type Vii Oi, Type Vii Osteogenesis Imperfecta, Type Iib, Formerly Oi2b, Formerly Oi Type 7 Osteogenesis Imperfecta 7 Oi2b Oi-Iib Oi Type Iib Oi-Vii Osteogenesis Imperfecta Perinatal Lethal Autosomal Recessive Osteogenesis Imperfecta Type Ii Autosomal Recessive Osteogenesis Imperfecta Type Iib
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Joubert Syndrome 8	JBTS8 Joubert Syndrome, Type 8
Bruck Syndrome	Osteogenesis Imperfecta With Congenital Joint Contractures Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome
Myopathy, Tubular Aggregate, 1	Tubular Aggregate Myopathy Tam Myopathy With Tubular Aggregates TAM1 Myopathy, Tubular Aggregate Tubular Aggregate Myopathy 1
Ehlers-Danlos Syndrome, Classic Type, 1	Ehlers-Danlos Syndrome, Type I EDSCL1 Ehlers-Danlos Syndrome Classic Type 1 Ehlers-Danlos Syndrome Type 1 Ehlers-Danlos Syndrome, Type I, Formerly Eds1, Formerly Ehlers-Danlos Syndrome, Severe Classic Type, Formerly Eds I, Formerly Ehlers-Danlos Syndrome, Gravis Type, Formerly Ehlers-Danlos Syndrome, Type 1 Type I Ehlers-Danlos Syndrome Eds1 Eds I Ehlers-Danlos Syndrome, Gravis Type Ehlers-Danlos Syndrome, Severe Classic Type Ehlers-Danlos Syndrome 1 Ehlers-Danlos, Classic Syndrome, Type 1 Ehlers-Danlos Syndrome Type 2
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Bone Development Disease
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18494	Ppib Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10947	PPIB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24976	Ppib Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPIB	VGNC	VGNC:33195
Macaca mulatta	PPIB	VGNC	VGNC:99227
Mus musculus	PPIB	MGD	MGI:97750
Canis familiaris	PPIB	VGNC	VGNC:44849
Felis catus	PPIB	VGNC	VGNC:104577
Rattus norvegicus	PPIB	RGD	RGD:620312
Others	PPIB	NCBI