NCBP3 - nuclear cap binding subunit 3 Gene

Also Known as ELG; C17orf85; HSA277841

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55421

Summary

Enables RNA 7-methylguanosine cap binding activity and mRNA binding activity. Involved in defense response to virus; mRNA export from nucleus; and snRNA export from nucleus. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in bone marrow (RPKM 6.9), placenta (RPKM 6.6) and 25 other tissues.

NCBP3 Products (2)

mRNA Protein Name
NM_001114118.3 NP_001107590.1 nuclear cap-binding protein subunit 3 isoform 1
NM_001398494.1 NP_001385423.1 nuclear cap-binding protein subunit 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RNA 7-methylguanosine cap binding IMP
IMP: Inferred from mutant phenotype
26382858 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
26382858 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
26382858 GOA
involved in mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
26382858 GOA
involved in snRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
26382858 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26382858 GOA
part of nuclear cap binding complex IPI
IPI: Inferred from physical interaction
26382858 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26382858 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCBP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NCBP3 Q53F19 KPNA4 Homo sapiens O00629
Y2H Array
32296183
Intra
NCBP3 Q53F19 KPNA4 Homo sapiens O00629
Pull Down
26382858
Intra
NCBP3 Q53F19 KPNA4 Homo sapiens O00629
Anti Tag CoIP
32960270
Intra
NCBP3 Q53F19 KPNA4 Homo sapiens O00629
Y2H Prey Pooling
32296183
Intra
NCBP3 Q53F19 NCBP1 Homo sapiens Q09161
Anti Tag CoIP
32960270
Intra
NCBP3 Q53F19 NCBP1 Homo sapiens Q09161
Pull Down
26382858
Intra
NCBP3 Q53F19 LENG8 Homo sapiens Q96PV6
Pull Down
26382858
Intra
NCBP3 Q53F19 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra
NCBP3 Q53F19 LENG8 Homo sapiens Q96PV6
Y2H Prey Pooling
32296183
Intra
NCBP3 Q53F19 LENG8 Homo sapiens Q96PV6
Anti Tag CoIP
32960270
Intra
NCBP3 Q53F19 LENG8 Homo sapiens Q96PV6
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08983 N4BP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09072 NCBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09073 NCBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10117 PCBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18676 Pcbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25162 Pcbp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown