945260-14-0
Chemical Structure
(S)-3-Hydroxy Midostaurin
Synonym(s): (S)-CGP52421
- CAS No.: 945260-14-0
- Formula:C35H30N4O5
- Molecular Weight:586.64
IUPAC Name: N-((5R,7R,8R,9S,14S)-14-hydroxy-8-methoxy-9-methyl-16-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide
InChIKey: ZZSBPGIGIUFJRA-AKIDMACVSA-N
SMILES: O[C@@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(C)[C@@H]([C@@H](C[C@](O6)([H])N7C5=C2C8=C7C=CC=C8)N(C(C9=CC=CC=C9)=O)C)OC)=O
Biological Activity: (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-3-Hydroxy Midostaurin | 96.07% | (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML). | ||||||||||||||||||||
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Keywords
