CISD1 - CDGSH iron sulfur domain 1 Gene

Homo sapiens

Also known as ZCD1; MDS029; C10orf70; mitoNEET

Gene ID: 55847 | Gene type: protein coding

About CISD1

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:58,269,162-58,289,586 (from NCBI)

This gene has 4 transcripts (splice variants), 227 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 13.4), small intestine (RPKM 9.9) and 23 other tissues.

Summary

This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]

CISD1 Products(1)

mRNA	Protein	Name
NM_018464.5	NP_060934.1	CDGSH iron-sulfur domain-containing protein 1

CISD1 Protein Structure

MitoNEET_N

zf-CDGSH

0
100
108 a.a.

Protein Preferred Names

Protein Names

CDGSH iron-sulfur domain-containing protein 1

zinc finger CDGSH-type domain 1

Recombinant CISD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76262	CISD1 Protein, Human (His)	Q9NZ45/NP_060934.1 (K32-T108)	≥95%

Related Diseases

Diseases

Alias

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Wolfram Syndrome 2

WFS2

Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2	FANCD2
Fad2	Fa4
Fancd	Fanconi Pancytopenia Type 4
Fanconi Anemia, Complementation Group D	Fanconi Pancytopenia, Type 4
Facd	Fanconi Anemia Complementation Group D

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135231	NL-1		99.72%	Unkown
HY-RS02723	CISD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CISD1	VGNC	VGNC:27371
Rattus norvegicus	CISD1	RGD	RGD:1309529
Mus musculus	CISD1	MGD	MGI:1261855
Others	CISD1	NCBI

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