PRNP - prion protein Gene

Also Known as CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5621

About PRNP

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,686,456-4,701,588 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and is associated with 13 phenotypes. Ubiquitous expression in brain (RPKM 148.7), ovary (RPKM 52.6) and 24 other tissues.

Summary

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

PRNP Products (12)

mRNA	Protein	Name
NM_000311.5	NP_000302.1	major prion protein preproprotein Prp precursor
NM_001080121.3	NP_001073590.1	major prion protein preproprotein Prp precursor
NM_001080122.3	NP_001073591.1	major prion protein preproprotein Prp precursor
NM_001080123.3	NP_001073592.1	major prion protein preproprotein Prp precursor
NM_001271561.3	NP_001258490.1	alternative prion protein isoform AltPrp
NM_183079.4	NP_898902.1	major prion protein preproprotein Prp precursor
NM_000311.5	NP_000302.1	major prion protein preproprotein Prp precursor
NM_001080121.3	NP_001073590.1	major prion protein preproprotein Prp precursor
NM_001080122.3	NP_001073591.1	major prion protein preproprotein Prp precursor
NM_001080123.3	NP_001073592.1	major prion protein preproprotein Prp precursor
NM_001271561.3	NP_001258490.1	alternative prion protein isoform AltPrp
NM_183079.4	NP_898902.1	major prion protein preproprotein Prp precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	24012003	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	22820466	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	11900542	GOA
enables cuprous ion binding	IMP IMP: Inferred from mutant phenotype	20564047	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16286452	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	16004966	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	30401430	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	30401430	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16286452	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23386614	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	16004966	GOA
NOT enables type 8 metabotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	24012003	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	24012003	GOA
acts upstream of or within cellular response to copper ion	IDA IDA: Inferred from direct assay	16254249	GOA
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	24012003	GOA
involved in positive regulation of glutamate receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24012003	GOA
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20564047	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	22820466	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	20564047	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	18419754	GOA
is active in dendrite	IDA IDA: Inferred from direct assay	24012003	GOA
located in inclusion body	IMP IMP: Inferred from mutant phenotype	20564047	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	16254249	GOA
located in membrane raft	IMP IMP: Inferred from mutant phenotype	23386614	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	21478263	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16254249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRNP Protein Structure

Prion_bPrPp

Prion

0
100
200
253 a.a.

Protein Preferred Names	Protein Names
major prion protein alternative prion protein	CD230 antigen

Protein Preferred Names

Protein Names

major prion protein

alternative prion protein

CD230 antigen

PRNP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRNP	P04156	MPG	Homo sapiens	P29372	IF	18482256
Intra	PRNP	P04156	MPG	Homo sapiens	P29372	Anti Tag CoIP	18482256
Intra	PRNP	P04156	MPG	Homo sapiens	P29372	Protein Array	18482256
Intra	PRNP	P04156	AZGP1	Homo sapiens	P25311	Anti Bait CoIP	28671123
Intra	PRNP	P04156	AZGP1	Homo sapiens	P25311	Confocal	28671123
Intra	PRNP	P04156	PIMREG	Homo sapiens	Q9BSJ6	IF	18482256
Intra	PRNP	P04156	PIMREG	Homo sapiens	Q9BSJ6	Anti Tag CoIP	18482256
Intra	PRNP	P04156	APP	Homo sapiens	P05067-4	Anti Bait CoIP	23236467
Intra	PRNP	P04156	PRDX1	Homo sapiens	Q06830	Anti Bait CoIP	28671123
Intra	PRNP	P04156	MAPT	Homo sapiens	P10636	Anti Bait CoIP	24028865
Intra	PRNP	P04156	F2RL1	Homo sapiens	P55085	Anti Bait CoIP	28298427
Intra	PRNP	P04156	F2RL1	Homo sapiens	P55085	BRET	28298427
Intra	PRNP	P04156	F2RL1	Homo sapiens	P55085	Ub Reconstruction	28298427
Intra	PRNP	P04156	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PRNP	P04156	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PRNP	P04156	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PRNP	P04156	AGO1	Homo sapiens	Q9UL18	Anti Bait CoIP	22484317
Intra	PRNP	P04156	AGO1	Homo sapiens	Q9UL18	Protein Array	18482256
Intra	PRNP	P04156	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	22484317
Cross	PRNP	P04156	Ago2	Mus musculus	Q8CJG0	Anti Bait CoIP	22484317
Intra	PRNP	P04156	HOXA1	Homo sapiens	P49639	IF	18482256
Intra	PRNP	P04156	HOXA1	Homo sapiens	P49639	Anti Tag CoIP	18482256
Intra	PRNP	P04156	FZD7	Homo sapiens	O75084	BRET	28298427
Intra	PRNP	P04156	FZD7	Homo sapiens	O75084	Anti Bait CoIP	28298427
Intra	PRNP	P04156	FZD7	Homo sapiens	O75084	Ub Reconstruction	28298427
Intra	PRNP	P04156	PLK3	Homo sapiens	Q9H4B4	IF	18482256
Intra	PRNP	P04156	PLK3	Homo sapiens	Q9H4B4	Anti Tag CoIP	18482256
Intra	PRNP	P04156	PLK3	Homo sapiens	Q9H4B4	Protein Array	18482256
Cross	PRNP	P04156	Prnp	Mus musculus	P04925	Pull Down	22285492
Intra	PRNP	P04156	APP	Homo sapiens	P05067	Anti Bait CoIP	24028865
Intra	PRNP	P04156	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	PRNP	P04156	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	PRNP	P04156	APP	Homo sapiens	P05067	SPR	16286452
Intra	PRNP	P04156	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	PRNP	P04156	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	Pull Down	23907583
Intra	PRNP	P04156	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	ELISA	23907583
Intra	PRNP	P04156	FHL1	Homo sapiens	Q13642	Protein Array	18482256
Intra	PRNP	P04156	FHL1	Homo sapiens	Q13642	Anti Bait CoIP	28671123
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	Light Scattering	16286452
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	X-Ray Diffraction	19204296
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	CD	19278656
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	Solution Sedimentation	18436646
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	NMR	19278656
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	SPR	16286452
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	EPR	18025469
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	EM	16286452
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	AFM	19278656
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	NMR	18436646
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	X-Ray Diffraction	19927125
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	TEM	18025469
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	Fluorescence Spectr	19278656
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	GMS	16286452
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	TEM	19278656
Intra	PRNP	P04156	PRNP	Homo sapiens	P04156	AFM	18436646
Cross	PRNP	P04156	PRNP	Bos taurus	P10279	CD	21920025
Cross	PRNP	P04156	PRNP	Bos taurus	P10279	Pull Down	22285492
Cross	PRNP	P04156	PRNP	Ovis aries	P23907	Pull Down	22285492

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRNP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74619	PRNP/CD230 Protein, Human (HEK293, Fc, solution)	P04156/NP_000302.1 (K23-G229)	≥ 90%, as determined by reducing SDS-PAGE.

PRNP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81980	Prion Protein Antibody (YA1725)	WB, IHC-P	Human, Mouse, Rat
HY-P81980A	Prion Protein Antibody (YA1725)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Fatal Familial Insomnia	Insomnia, Fatal Familial FFI Familial Fatal Insomnia Insomnia Familial Fatal Insomnia Fatal Familial Insomnia, Fatal, Familial Ffi - [Fatal Familial Insomnia]
Gerstmann-Straussler Disease	Gerstmann-Straussler-Scheinker Disease Gerstmann-Straussler-Scheinker Syndrome Prion Dementia Cerebral Amyloid Angiopathy, Prnp-Related GSD Gss Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns Amyloidosis, Cerebral, With Spongiform Encephalopathy Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type Amyloidosis Cerebral With Spongiform Encephalopathy Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System Encephalopathy Subacute Spongiform Gerstmann-Straussler Type Gssd Gerstmann Straussler Scheinker Syndrome Cerebral Amyloidosis With Spongiform Encephalopathy Subacute Spongiform Encephalopathy Gerstmann-Straussler Type Gluthathione Synthetase Deficiency Gerstmann Straussler Syndrome
Huntington Disease-Like 1	HDL1 Huntington-Like Neurodegenerative Disorder 1 Hln1 Huntington'S Disease-Like 1 Early-Onset Prion Disease With Prominent Psychiatric Features Huntington-Like Neurodegenerative Disorder, Autosomal Dominant Prion Disease, Early-Onset, With Prominent Psychiatric Features Autosomal Dominant Huntington-Like Neurodegenerative Disorder Huntington Disease-Like, Type 1
Spongiform Encephalopathy With Neuropsychiatric Features	SENF
Kuru	Kuru, Susceptibility To Kuru Encephalopathy Kuru Encephalitis Kuru Disease
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Inherited Human Prion Disease	Inherited Prion Disease Familial Prion Disease Genetic Human Prion Disease
Familial Alzheimer-Like Prion Disease
Prp Systemic Amyloidosis	Chronic Diarrhea With Hsan Chronic Diarrhea With Hereditary Sensory And Autonomic Neuropathy Prion Protein Systemic Amyloidosis
Scrapie
Chronic Wasting Disease	Wasting Disease, Chronic
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related	Primary Progressive Aphasia Grn-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions Frontotemporal Dementia, Ubiquitin-Positive Aphasia, Primary Progressive Ppa Ftld-Tdp, Grn-Related Frontotemporal Dementia With Tdp43 Inclusions, Grn-Related Ftldu Ftdu Dementia, Hereditary Dysphasic Disinhibition Hddd Primary Progressive Aphasia Syndrome Mesulam Syndrome Ubiquitin-Positive Frontotemporal Dementia UP-FTD Tau-Negative Frontotemporal Dementia Linked To Chromosome 17 Aphasia Primary Progressive Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions, Susceptibility To Aphasia, Primary Progressive, Susceptibility To Frontotemporal Dementia
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Encephalopathy	Brain Diseases Encephalopathies Toxic Encephalopathy Toxic Brain Fever Toxic Brain Inflammation Toxic Brain Stem Inflammation Toxic Cerebral Fever Toxic Cerebrospinal Fever Toxic Cerebrospinal Inflammation Encephalopathy Nec Encephalopathy Nos Encephalopathy Disease Encephalopathy Syndrome
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Akinetic Mutism	Coma Vigilans
Aphasia
Wilson Disease	Hepatolenticular Degeneration WD Wilson'S Disease WND Westphal-Strumpell Syndrome Copper Storage Disease Cerebral Pseudosclerosis Westphal Pseudosclerosis Hepatolenticular Degeneration Syndrome Copper Retention Hepatocerebral Degeneration Kinnier-Wilson Disease Neurohepatic Degeneration Progressive Hepatolenticular Degeneration Lenticular Degenerative Disease Wilson'S Syndrome Lenticular Syndrome
Visual Cortex Disease	Visual Cortex Dysfunction Visual Cortex Disorder Visual Cortical Disorder Disease Of Visual Cortex
Vascular Dementia	Dementia, Vascular Multi Infarct Dementia Multifocal Dementia Dementia Vascular Vascular Dementia, Susceptibility To Dementia, Multi-Infarct Multi-Infarct Dementia
Visual Pathway Disease	Disorder Of Visual Pathways
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Dentatorubral-Pallidoluysian Atrophy	DRPLA Naito-Oyanagi Disease Haw River Syndrome Myoclonic Epilepsy With Choreoathetosis Nod Ataxia, Chorea, Seizures, And Dementia Dentatorubropallidoluysian Atrophy Hrs Naito Oyanagi Disease Dentatorubral Pallidoluysian Atrophy Dentatorubro-Pallidoluysian Atrophy Myoclonic Epilepsies, Progressive Atrophy, Pallidoluysian, Dentatorubral
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Louping Ill
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Agraphia
Ideomotor Apraxia	Apraxia, Ideomotor Classic Apraxia Ideomotor Dyspraxia Limb-Kinetic Apraxia Transcortical Apraxia
Spinocerebellar Ataxia 12	Spinocerebellar Ataxia Type 12 SCA12 Ataxia, Spinocerebellar, Type 12
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Gerstmann Syndrome	Aphasia-Angular Gyrus Syndrome Developmental Gerstmann Syndrome Gs Gerstmann Badal Syndrome Gerstmann Tetrad Gerstmann'S Syndrome Developmental Gerstmann'S Syndrome
Writing Disorder
Gait Apraxia
Cortical Blindness	Blindness, Cortical
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Dystonia 25	DYT25 Dystonia-25 Dystonia, Type 25
Torsion Dystonia 2	Dystonia 2, Torsion, Autosomal Recessive
Alexia	Dyslexia Dyslexia, Acquired Acquired Dyslexia Aphemesthaesia
Cerebral Amyloid Angiopathy, Itm2b-Related, 1	Dementia, Familial British Fbd Presenile Dementia With Spastic Ataxia Familial British Dementia Abri Amyloidosis Cerebral Amyloid Angiopathy, British Type Itm2b-Related Cerebral Amyloid Angiopathy 1 Familial Dementia, British Type Cerebral Amyloid Angiopathy, Itm2b-Related 1 CAA-ITM2B1 Cerebral Amyloid Angiopathy British Type Dementia, Familial, British
Mutism
Visual Agnosia	Primary Visual Agnosia
Pseudobulbar Palsy	Pseudobulbar Paralysis
Spinocerebellar Ataxia 45	SCA45 Spinocerebellar Ataxia Type 45
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Akinetopsia
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Myopathy	Muscular Diseases Myopathies
Cortical Deafness
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Warburg Micro Syndrome 3	WARBM3 Micro Syndrome 3
Warburg Micro Syndrome 2	WARBM2 Micro Syndrome 2
Choreatic Disease	Chorea Hereditary Chorea
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Movement Disease	Movement Disorders Movement Disorder
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11188	PRNP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18367	Prnp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24846	Prnp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992294	Anti-PRNP Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRNP	VGNC	VGNC:81156
Rattus norvegicus	PRNP	RGD	RGD:3410
Canis familiaris	PRNP	VGNC	VGNC:45004
Bos taurus	PRNP	VGNC	VGNC:33356
Macaca mulatta	PRNP	VGNC	VGNC:76424
Mus musculus	PRNP	MGD	MGI:97769
Others	PRNP	NCBI