POGK - pogo transposable element derived with KRAB domain Gene

Also Known as BASS2; KRBOX2; LST003

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57645

About POGK

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:166,839,475-166,856,359 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 8.9), lung (RPKM 8.9) and 25 other tissues.

Summary

The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008]

POGK Products (2)

mRNA Protein Name
NM_001314014.2 NP_001300943.1 pogo transposable element with KRAB domain isoform 2
NM_017542.5 NP_060012.3 pogo transposable element with KRAB domain isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POGK Protein Structure

KRAB

KRAB: KRAB box (49 - 87)

BrkDBD

BrkDBD: Brinker DNA-binding domain (195 - 247)

HTH_Tnp_Tc5

HTH_Tnp_Tc5: Tc5 transposase DNA-binding domain (260 - 322)

DDE_1

DDE_1: DDE superfamily endonuclease (356 - 567)

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  • 500
  • 609 a.a.
Protein Preferred Names Protein Names

pogo transposable element with KRAB domain

  • KRAB box domain containing 2

POGK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POGK Q9P215 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
Intra
POGK Q9P215 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cervical Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Cervix

  • Adenosquamous Cell Carcinoma Of The Cervix Uteri
Non-Invasive Bladder Papillary Urothelial Neoplasm

  • Bladder Papillary Neoplasm Of Low Malignant Potential

  • Bladder Punlmp

  • Papillary Urothelial Neoplasm Of Low Malignant Potential

  • Papillary Transitional Cell Neoplasm Of Low Malignant Potential
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10813 POGK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus POGK RGD RGD:1308951
Bos taurus POGK VGNC VGNC:33107
Macaca mulatta POGK VGNC VGNC:76066
Felis catus POGK VGNC VGNC:64278
Canis familiaris POGK VGNC VGNC:44768
Mus musculus POGK MGD MGI:1918842
Others POGK NCBI