POGK - pogo transposable element derived with KRAB domain Gene

Homo sapiens

Also known as BASS2; KRBOX2; LST003

Gene ID: 57645 | Gene type: protein coding

About POGK

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:166,839,475-166,856,359 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 8.9), lung (RPKM 8.9) and 25 other tissues.

Summary

The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008]

POGK Products(2)

mRNA	Protein	Name
NM_001314014.2	NP_001300943.1	pogo transposable element with KRAB domain isoform 2
NM_017542.5	NP_060012.3	pogo transposable element with KRAB domain isoform 1

POGK Protein Structure

KRAB

BrkDBD

HTH_Tnp_Tc5

DDE_1

0
100
200
300
400
500
609 a.a.

Protein Preferred Names

Protein Names

pogo transposable element with KRAB domain

KRAB box domain containing 2

Related Diseases

Diseases

Alias

Cervical Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Cervix

Adenosquamous Cell Carcinoma Of The Cervix Uteri

Non-Invasive Bladder Papillary Urothelial Neoplasm

Bladder Papillary Neoplasm Of Low Malignant Potential	Bladder Punlmp
Papillary Urothelial Neoplasm Of Low Malignant Potential	Papillary Transitional Cell Neoplasm Of Low Malignant Potential

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10813	POGK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POGK	RGD	RGD:1308951
Bos taurus	POGK	VGNC	VGNC:33107
Macaca mulatta	POGK	VGNC	VGNC:76066
Felis catus	POGK	VGNC	VGNC:64278
Canis familiaris	POGK	VGNC	VGNC:44768
Mus musculus	POGK	MGD	MGI:1918842