GORASP1 - golgi reassembly stacking protein 1 Gene

Homo sapiens

Also known as P65; GOLPH5; GRASP65

Gene ID: 64689 | Gene type: protein coding

About GORASP1

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:39,096,599-39,107,627 (from NCBI)

This gene has 58 transcripts (splice variants), 246 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.9), brain (RPKM 12.1) and 25 other tissues.

Summary

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a Caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in Apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GORASP1 Products(5)

mRNA	Protein	Name
NM_001278789.2	NP_001265718.1	Golgi reassembly-stacking protein 1 isoform 2
NM_001278790.2	NP_001265719.1	Golgi reassembly-stacking protein 1 isoform 3
NM_001410726.1	NP_001397655.1	Golgi reassembly-stacking protein 1 isoform 4
NM_001410731.1	NP_001397660.1	Golgi reassembly-stacking protein 1 isoform 5
NM_031899.4	NP_114105.1	Golgi reassembly-stacking protein 1 isoform 1

GORASP1 Protein Structure

GRASP55_65

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

Golgi reassembly-stacking protein 1

Golgi peripheral membrane protein p65

Related Diseases

Diseases

Alias

Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia	SMC1
Smc	Smith Mccort Dysplasia
Smith-Mccort Dwarfism

Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome	DMC
Dmc Disease	Pseudo-Morquio Disease Type I
Dmc Syndrome

Achondrogenesis

Achondrogenesis Syndrome

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05601	GORASP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GORASP1	VGNC	VGNC:29498
Macaca mulatta	GORASP1	VGNC	VGNC:72951
Felis catus	GORASP1	VGNC	VGNC:62647
Canis familiaris	GORASP1	VGNC	VGNC:41351
Mus musculus	GORASP1	MGD	MGI:1921748
Rattus norvegicus	GORASP1	RGD	RGD:621122

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