GORASP1 - golgi reassembly stacking protein 1 Gene

Also Known as P65; GOLPH5; GRASP65

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64689

About GORASP1

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:39,096,599-39,107,627 (from NCBI)

This gene has 58 transcripts (splice variants), 246 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.9), brain (RPKM 12.1) and 25 other tissues.

Summary

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a Caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in Apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GORASP1 Products (5)

mRNA	Protein	Name
NM_001278789.2	NP_001265718.1	Golgi reassembly-stacking protein 1 isoform 2
NM_001278790.2	NP_001265719.1	Golgi reassembly-stacking protein 1 isoform 3
NM_001410726.1	NP_001397655.1	Golgi reassembly-stacking protein 1 isoform 4
NM_001410731.1	NP_001397660.1	Golgi reassembly-stacking protein 1 isoform 5
NM_031899.4	NP_114105.1	Golgi reassembly-stacking protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16489344	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi ribbon formation	IGI IGI: Inferred from genetic interaction	33301566	GOA
involved in establishment of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21884936	GOA
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	21572988	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18045989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GORASP1 Protein Structure

GRASP55_65

0
100
200
300
400
440 a.a.

Protein Preferred Names	Protein Names
Golgi reassembly-stacking protein 1	Golgi peripheral membrane protein p65

GORASP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GORASP1	Q9BQQ3	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	25416956
Cross	GORASP1	Q9BQQ3	P0DTD1-PRO_0000449630	SARS-CoV-2	P0DTD1-PRO_0000449630	Y2H Array	36217030
Intra	GORASP1	Q9BQQ3	SCRN1	Homo sapiens	Q12765	Y2H Array	25416956
Intra	GORASP1	Q9BQQ3	SCRN1	Homo sapiens	Q12765	Validated Y2H	25416956
Intra	GORASP1	Q9BQQ3	AGPS	Homo sapiens	O00116	Y2H Prey Pooling	25416956
Intra	GORASP1	Q9BQQ3	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GORASP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82590	GRASP65 Antibody (YA2335)	WB, IHC-P, ICC/IF, FC, IP	Human

Related Diseases

Diseases	Alias
Smith-Mccort Dysplasia 1	Smith-Mccort Dysplasia SMC1 Smc Smith Mccort Dysplasia Smith-Mccort Dwarfism
Dyggve-Melchior-Clausen Disease	Dyggve-Melchior-Clausen Syndrome DMC Dmc Disease Pseudo-Morquio Disease Type I Dmc Syndrome
Achondrogenesis	Achondrogenesis Syndrome
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11596	NOTA-Asp2-αvβ6L		/	Unkown
HY-RS05601	GORASP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GORASP1	VGNC	VGNC:29498
Macaca mulatta	GORASP1	VGNC	VGNC:72951
Felis catus	GORASP1	VGNC	VGNC:62647
Canis familiaris	GORASP1	VGNC	VGNC:41351
Mus musculus	GORASP1	MGD	MGI:1921748
Rattus norvegicus	GORASP1	RGD	RGD:621122
Others	GORASP1	NCBI