SCRN1 - secernin 1 Gene

Also Known as SES1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9805

About SCRN1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:29,920,103-29,990,289 (from NCBI)

This gene has 10 transcripts (splice variants), 132 orthologues and 2 paralogues. Broad expression in brain (RPKM 69.1), testis (RPKM 17.1) and 22 other tissues.

Summary

This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

SCRN1 Products (4)

mRNA Protein Name
NM_001145513.1 NP_001138985.1 secernin-1 isoform a
NM_001145514.1 NP_001138986.1 secernin-1 isoform b
NM_001145515.2 NP_001138987.1 secernin-1 isoform c
NM_014766.5 NP_055581.3 secernin-1 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear membrane IDA
IDA: Inferred from direct assay
10942595 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10942595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCRN1 Protein Structure

Peptidase_C69

Peptidase_C69: Peptidase family C69 (81 - 229)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

secernin-1

SCRN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCRN1 Q12765 GORASP1 Homo sapiens Q9BQQ3
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Osteosarcoma

  • Osteogenic Sarcoma Of Breast

  • Breast Extraskeletal Osteosarcoma
Gallbladder Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Gallbladder

  • Epidermoid Gallbladder Carcinoma
Pick Disease Of Brain

  • Pick Disease

  • Pick'S Disease

  • Pick Disease Of The Brain

  • Lobar Atrophy Of Brain

  • Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

  • Behavioral Variant Of Frontotemporal Dementia

  • Dementia In Pick'S Disease

  • Lobar Atrophy Of The Brain

  • Bvftd

  • Bv-Ftd

  • PIDB

  • Picks Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12563 SCRN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SCRN1 VGNC VGNC:34366
Canis familiaris SCRN1 VGNC VGNC:54794
Macaca mulatta SCRN1 VGNC VGNC:77083
Mus musculus SCRN1 MGD MGI:1917188
Felis catus SCRN1 VGNC VGNC:80713
Rattus norvegicus SCRN1 RGD RGD:1560999
Others SCRN1 NCBI