BMPR1A - bone morphogenetic protein receptor type 1A Gene

Also Known as ALK3; SKR5; ALK-3; CD292; ACVRLK3; BMPR-1A; 10q23del

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 657

About BMPR1A

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:86,755,763-86,927,969 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues, 11 paralogues and is associated with 83 phenotypes. Ubiquitous expression in thyroid (RPKM 14.8), endometrium (RPKM 10.0) and 23 other tissues.

Summary

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta Superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

BMPR1A Products (42)

mRNA	Protein	Name
XM_011540103.3	XP_011538405.1	bone morphogenetic protein receptor type-1A isoform X1
NM_001406574.1	NP_001393503.1	bone morphogenetic protein receptor type-1A isoform 3
XM_047425678.1	XP_047281634.1	bone morphogenetic protein receptor type-1A isoform X1
NM_001406589.1	NP_001393518.1	bone morphogenetic protein receptor type-1A isoform 6
NM_001406588.1	NP_001393517.1	bone morphogenetic protein receptor type-1A isoform 5
NM_001406559.1	NP_001393488.1	bone morphogenetic protein receptor type-1A isoform 1
XM_047425677.1	XP_047281633.1	bone morphogenetic protein receptor type-1A isoform X1
NM_001406580.1	NP_001393509.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406579.1	NP_001393508.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406570.1	NP_001393499.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406564.1	NP_001393493.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406566.1	NP_001393495.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406575.1	NP_001393504.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406567.1	NP_001393496.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406562.1	NP_001393491.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406565.1	NP_001393494.1	bone morphogenetic protein receptor type-1A isoform 3
NR_176211.1
XM_047425679.1	XP_047281635.1	bone morphogenetic protein receptor type-1A isoform X1
NM_001406584.1	NP_001393513.1	bone morphogenetic protein receptor type-1A isoform 5
XM_047425680.1	XP_047281636.1	bone morphogenetic protein receptor type-1A isoform X1
NM_001406578.1	NP_001393507.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406586.1	NP_001393515.1	bone morphogenetic protein receptor type-1A isoform 5
XM_047425676.1	XP_047281632.1	bone morphogenetic protein receptor type-1A isoform X1
NR_176213.1
NM_001406581.1	NP_001393510.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_004329.3	NP_004320.2	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406576.1	NP_001393505.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406561.1	NP_001393490.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406568.1	NP_001393497.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406560.1	NP_001393489.1	bone morphogenetic protein receptor type-1A isoform 2
NM_001406587.1	NP_001393516.1	bone morphogenetic protein receptor type-1A isoform 5
XM_011540104.3	XP_011538406.1	bone morphogenetic protein receptor type-1A isoform X1
NM_001406583.1	NP_001393512.1	bone morphogenetic protein receptor type-1A isoform 4
NM_001406585.1	NP_001393514.1	bone morphogenetic protein receptor type-1A isoform 5
NM_001406569.1	NP_001393498.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406571.1	NP_001393500.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406572.1	NP_001393501.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406582.1	NP_001393511.1	bone morphogenetic protein receptor type-1A isoform 3
NM_001406573.1	NP_001393502.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NR_176212.1
NM_001406563.1	NP_001393492.1	bone morphogenetic protein receptor type-1A isoform 3 precursor
NM_001406577.1	NP_001393506.1	bone morphogenetic protein receptor type-1A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables BMP binding	IPI IPI: Inferred from physical interaction	18184661	GOA
enables BMP receptor activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables SMAD binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10881198	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18436533	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables transforming growth factor beta receptor activity, type I	IDA IDA: Inferred from direct assay	9136927	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	9389648	GOA
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	24882581	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	24882581	GOA
involved in cellular response to BMP stimulus	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in immune response	IMP IMP: Inferred from mutant phenotype	16886151	GOA
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	18667463	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	9389648	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	24882581	GOA
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	18436533	GOA
acts upstream of positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24882581	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	18436533	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18667463	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	36641752	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with caveola	IMP IMP: Inferred from mutant phenotype	15657086	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	24904118	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15657086	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMPR1A Protein Structure

Activin_recp

TGF_beta_GS

Pkinase

0
100
200
300
400
500
532 a.a.

Protein Preferred Names	Protein Names
bone morphogenetic protein receptor type-1A	BMP type-1A receptor activin A receptor, type II-like kinase 3 activin receptor-like kinase 3 bone morphogenetic protein receptor, type IA serine/threonine-protein kinase receptor R5

BMPR1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BMPR1A	P36894	BMP2	Homo sapiens	P12643	ELISA	19804412
Intra	BMPR1A	P36894	BMP4	Homo sapiens	P12644	SPR	20860622
Intra	BMPR1A	P36894	GDF5	Homo sapiens	P43026	SPR	19229295

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BMPR1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7484	BMPR1A/ALK-3 Protein, Human (HEK293, Fc-His)	P36894 (Q24-R152)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75594	BMPR1A/ALK-3 Protein, Human (HEK293, His)	P36894 (Q24-R152)	≥ 85%, as determined by reducing SDS-PAGE.

BMPR1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84287	BMPR1A Antibody (YA3984)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84287A	BMPR1A Antibody (YA3984)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P87255	BMPR1A Antibody	WB, IHC-P, IHC-F, IF-Tissue	Human, Rat

Related Diseases

Diseases	Alias
Juvenile Polyposis Syndrome	JPS Juvenile Intestinal Polyposis Jip Pji Juvenile Gastrointestinal Polyposis Juvenile Polyposis Polyposis, Juvenile Intestinal Polyposis, Familial, Of Entire Gastrointestinal Tract Polyposis Familial Of Entire Gastrointestinal Tract Polyposis Juvenile Intestinal Polyposis Syndrome, Juvenile
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Tumor Predisposition Syndrome	TPDS Tumor Predisposition
Lipoma Of Colon	Colonic Lipoma Colon Lipoma
Persistent Mullerian Duct Syndrome	Persistent Müllerian Duct Syndrome Pmds Persistent Oviduct Syndrome Persistent Muellerian Duct Syndrome Female Genital Ducts In Otherwise Normal Male Hernia Uteri Inguinale Persistent Mullerian Duct Syndrome, Types 1 And 2 Persistent Mullerian Derivatives
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Brachydactyly
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes	Cronkhite-Canada Syndrome Gastric Cronkhite Canada Polyposis Cronkhite-Canada Disease Polyposis Skin Pigmentation Alopecia Fingernail Changes Gastrointestinal Polyposis-Ectodermal Changes Syndrome Gastrointestinal Polyposis-Skin Pigmentation-Alopecia-Fingernail Changes Syndrome Polyposis, Gastrointestinal, With Ectodermal Changes
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Diffuse Gastric Cancer	Hereditary Diffuse Gastric Adenocarcinoma Hereditary Diffuse Gastric Cancer Signet Cell Adenocarcinoma Signet Ring Cell Carcinoma Signet Ring Cell Gastric Carcinoma Signet Ring Gastric Carcinoma Fdgc Familial Diffuse Cancer Of Stomach Familial Diffuse Gastric Cancer Gastric Cancer, Familial Diffuse Gastric Cancer, Hereditary Diffuse Hdgc Hereditary Diffuse Cancer Of Stomach Diffuse Gastric Cancer Syndrome Cancer, Gastric, Diffuse Carcinoma, Signet Ring Cell Gastric Signet Ring Carcinoma
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Pseudohermaphroditism	Indeterminate Sex And Pseudohermaphroditism
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Hemochromatosis Type 2	Juvenile Hemochromatosis Juvenile Hereditary Hemochromatosis Hfe2 Jhh Hemochromatosis Juvenile Iron Overload Disease Juvenile Hemochromatosis, Juvenile Hemochromatosis, Type 2 Hemochromatosis Hemochromatosis, Type 1
Diffuse Gastric And Lobular Breast Cancer Syndrome	Hereditary Diffuse Gastric Cancer HDGC LBC Familial Diffuse Gastric Cancer Fdgc Hereditary Diffuse Gastric Adenocarcinoma Breast Cancer, Lobular Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate DGLBC Gastric Cancer, Hereditary Diffuse Gastric Cancer, Familial Diffuse Breast Cancer, Lobular Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate E-Cadherin-Associated Hereditary Gastric Cancer Familial Diffuse Cancer Of Stomach Hereditary Diffuse Cancer Of Stomach Gastric Cancer Familial Diffuse Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate Cancer, Gastric, Hereditary Diffuse
Large Intestine Lipoma	Lipoma Of Large Intestine Colorectal Lipoma
Intussusception	Intussusception Of Intestine Invagination Of Intestine Or Colon
Atrioventricular Septal Defect	AVSD Atrioventricular Canal Defect Avcd Endocardial Cushion Defect Ecd Avc Defect Atrioventricular Septal Defect, Susceptibility To, 1 Atrioventricular Septal Defect 1 Endocardial Cushion Defects Septal Defect, Atrioventricular Atrioventricular Defect With Atrial Shunting Only Incomplete Atrioventricular Septal Defect With Isolated Atrial Component Incomplete Atrioventricular Canal Defect With Isolated Atrial Component Primum Atrial Septal Defect Partial Atrioventricular Canal Defect With Isolated Atrial Component Partial Atrioventricular Septal Defect, Ostium Primum Type Ostium Primum Atrial Septal Defect Partial Atrioventricular Canal Defect Partial Atrioventricular Septal Defect Atrial Septum Primum Defect Atrioventricular Canal Defect With Isolated Ventricular Component Atrioventricular Canal Defect With Isolated Ventricular Communication Atrioventricular Septal Defect With Isolated Ventricular Component Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect Intermediate Atrioventricular Canal Defect Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices Intermediate Atrioventricular Septal Defect Transitional Atrioventricular Canal Defect Transitional Atrioventricular Septal Defect Complete Atrioventricular Canal With Atrial And Ventricular Components Complete Atrioventricular Canal Defect Complete Atrioventricular Septal Defect
Proximal Symphalangism	Cushing'S Symphalangism Symphalangism, Proximal Hereditary Absence Of Proximal Interphalangeal Joints Strasburger-Hawkins-Eldridge Syndrome Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome Symphalangism, Proximal, 1a Symphalangism, Proximal, 1b Vessel'S Syndrome Symphalangism, Cushing Type
Hereditary Mixed Polyposis Syndrome	Hmps
Cowden Syndrome 1	Pten Hamartoma Tumor Syndrome Bannayan-Riley-Ruvalcaba Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Lhermitte-Duclos Syndrome Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Familial Polyposis Coli Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome	Juvenile Polyposis-Hereditary Hemorrhagic Telangiectasia Syndrome JPHT Jp/Hht Syndrome Juvenile Polyposis With Hereditary Hemorrhagic Telangiectasia Jps/Hht Telangiectasia, Hereditary Hemorrhagic, With Juvenile Polyposis Coli Polyposis, Generalized Juvenile, With Pulmonary Arteriovenous Malformation Jp-Hht JP/HHT Polyposis, Juvenile/Hereditary Hemorrhagic Telangiectasia Syndrome
Chromosome 10q23 Deletion Syndrome
Telangiectasis	Telangiectasia
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Leber Congenital Amaurosis 17	LCA17 Leber Congenital Amaurosis, Type 17
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Juvenile Polyposis Of Infancy	Infantile Juvenile Polyposis Syndrome
Lung Combined Large Cell Neuroendocrine Carcinoma	Combined Large Cell Neuroendocrine Carcinoma Of Lung Pulmonary Combined Large Cell Neuroendocrine Carcinoma Combined Large Cell Lung Neuroendocrine Carcinoma
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Familial Adenomatous Polyposis 2	Mutyh-Related Attenuated Familial Adenomatous Polyposis FAP2 Colorectal Adenomatous Polyposis, Autosomal Recessive Adenomas, Multiple Colorectal Mutyh-Associated Polyposis Mutyh-Related Attenuated Familial Polyposis Coli Mutyh-Related Attenuated Fap Adenomas, Multiple Colorectal, Autosomal Recessive Mutyh-Related Afap Adenomas Multiple Colorectal Autosomal Recessive Colorectal Adenomatous Polyposis Autosomal Recessive Adenomatous Polyposis, Familial, Type 2
Protein-Losing Enteropathy	Protein-Losing Enteropathies Enteropathy, Exudative Exudative Enteropathy Ple - [Protein-Losing Enteropathy]
Atrial Heart Septal Defect	Atrial Septal Defect Atrial Septal Defects Atrioseptal Defect Auricular Septal Defect Congenital Atrial Septal Defect Interatrial Septal Defect Interauricular Septal Defect Heart Septal Defects, Atrial Septal Defect, Atrial
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Orofacial Cleft	Cleft, Orofacial
Polyposis Syndrome, Hereditary Mixed, 2	HMPS2 Hereditary Mixed Polyposis Syndrome 2 Polyposis Syndrome, Mixed Hereditary 2 Polyposis Syndrome, Hereditary Mixed, Type 2
Split-Hand/Foot Malformation 2	SHFM2 Shfd2 Shsf2 Split Hand/Foot Malformation 2 Split Hand-Foot Malformation 2 Split-Hand/Split-Foot Anomaly, X-Linked Split-Hand/Foot Deformity 2 Split Hand/Foot Malformation X-Linked Split Hand Foot Anomaly - X-Linked Split Hand Foot Deformity 2
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Familial Colorectal Cancer Type X	Fcctx

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4087	Cys(Npys)-(Arg)9		/	Unkown
HY-RS01546	BMPR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01547	Bmpr1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01548	Bmpr1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174775	Human BMPR1A mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BMPR1A	VGNC	VGNC:38484
Macaca mulatta	BMPR1A	VGNC	VGNC:100301
Mus musculus	BMPR1A	MGD	MGI:1338938
Felis catus	BMPR1A	VGNC	VGNC:60137
Rattus norvegicus	BMPR1A	RGD	RGD:70989
Bos taurus	BMPR1A	VGNC	VGNC:26524
Others	BMPR1A	NCBI