BMPR1A Antibody (YA3984)(PBS only)
(Synonyms: ALK3; SKR5; CD292; ACVRLK3; 10q23del)BMPR1A Antibody (YA3984) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMPR1A.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:200-1:1000 | 1:200-1000 | 1:200-1:400 | 1:10000 |
Product Details
BMPR1A Antibody (YA3984) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMPR1A.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 60 kDa
Purified recombinant fragment of human BMPR1A (AA: 179-378 ) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BMPR1A is an On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell surface
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Expression
Tissue_specificity:Highly expressed in skeletal muscle -
Subunit
Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation (PubMed:24098149). Interacts with BMP4 (PubMed:8006002). Interacts with SCUBE3 (PubMed:33308444). Interacts with TSC22D1/TSC-22 (PubMed:21791611). Interacts with BMP2; the interaction may induce HAMP expression (PubMed:10881198, PubMed:15064755, PubMed:17295905, PubMed:18937504, PubMed:31800957). Interacts with BMP6 (PubMed:31800957). Interacts with heterodimers composed of BMP2 and BMP6 in vitro; the interaction may induce HAMP expression (PubMed:31800957). Interacts with TGFBR3 (PubMed:19726563)
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SwissProt ID
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Synonyms
ALK3; SKR5; CD292; ACVRLK3; 10q23del
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