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SUPT6H - SPT6 homolog, histone chaperone and transcription elongation factor Gene

Also Known as SPT6; SPT6H; emb-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6830

About SUPT6H

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,662,205-28,702,679 (from NCBI)

This gene has 12 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in bone marrow (RPKM 15.3), ovary (RPKM 14.3) and 25 other tissues.

Summary

Enables histone binding activity. Involved in negative regulation of histone H3-K27 methylation and positive regulation of transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Predicted to be active in transcriptionally active chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SUPT6H Products (4)

mRNA	Protein	Name
NM_001320755.2	NP_001307684.1	transcription elongation factor SPT6
NM_003170.5	NP_003161.2	transcription elongation factor SPT6
NM_001320755.2	NP_001307684.1	transcription elongation factor SPT6
NM_003170.5	NP_003161.2	transcription elongation factor SPT6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables histone binding	IDA IDA: Inferred from direct assay	10933715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10933715	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17234882	GOA
involved in transcription elongation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	23503590	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT6H Protein Structure

SPT6_acidic

HTH_44

YqgF

HHH_7

DLD

SH2_2

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1726 a.a.

Protein Preferred Names	Protein Names
transcription elongation factor SPT6	histone chaperone suppressor of Ty6

SUPT6H Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SUPT6H	Q7KZ85	ERBB2	Homo sapiens	P04626	Protein Array	16273093

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ichthyosis, Congenital, Autosomal Recessive 11	Autosomal Recessive Congenital Ichthyosis 11 Ichthyosis With Hypotrichosis, Autosomal Recessive Arih Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis Autosomal Recessive Ichthyosis With Hypotrichosis ARCI11 Ifah Hypotrichosis-Congenital Ichthyosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome Ichthyosis-Hypotrichosis Syndrome Ifah Syndrome Ihs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14039	SUPT6H Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUPT6H	RGD	RGD:1309290
Mus musculus	SUPT6H	MGD	MGI:107726
Macaca mulatta	SUPT6H	VGNC	VGNC:78057
Canis familiaris	SUPT6H	VGNC	VGNC:49096
Bos taurus	SUPT6H	VGNC	VGNC:50619
Felis catus	SUPT6H	VGNC	VGNC:65850
Others	SUPT6H	NCBI