Mlip - muscular LMNA-interacting protein Gene
Also Known as CIP; 2310046A06Rik
Species: Mus musculus
Gene Type: protein coding
Gene ID: 69642
Summary
Enables lamin binding activity and transcription corepressor activity. Involved in negative regulation of cardiac muscle hypertrophy in response to stress. Acts upstream of or within negative regulation of cardiac muscle hypertrophy and negative regulation of transcription by RNA polymerase II. Located in PML body; nuclear envelope; and sarcolemma. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Mlip Products (36)
| mRNA | Protein | Name |
|---|---|---|
| NM_001368955.1 | NP_001355884.1 | muscular LMNA-interacting protein isoform 1 |
| NM_001368956.1 | NP_001355885.1 | muscular LMNA-interacting protein isoform 2 |
| NM_001368957.1 | NP_001355886.1 | muscular LMNA-interacting protein isoform 3 |
| NM_001368958.1 | NP_001355887.1 | muscular LMNA-interacting protein isoform 4 |
| NM_001368959.1 | NP_001355888.1 | muscular LMNA-interacting protein isoform 5 |
| NM_001368960.1 | NP_001355889.1 | muscular LMNA-interacting protein isoform 6 |
| NM_001368961.1 | NP_001355890.1 | muscular LMNA-interacting protein isoform 7 |
| NM_001368962.1 | NP_001355891.1 | muscular LMNA-interacting protein isoform 8 |
| NM_001368963.1 | NP_001355892.1 | muscular LMNA-interacting protein isoform 9 |
| NM_001368964.1 | NP_001355893.1 | muscular LMNA-interacting protein isoform 10 |
| NM_001368965.1 | NP_001355894.1 | muscular LMNA-interacting protein isoform 11 |
| NM_001368966.1 | NP_001355895.1 | muscular LMNA-interacting protein isoform 12 |
| NM_001368967.1 | NP_001355896.1 | muscular LMNA-interacting protein isoform 13 |
| NM_001368968.1 | NP_001355897.1 | muscular LMNA-interacting protein isoform 14 |
| NM_001368969.1 | NP_001355898.1 | muscular LMNA-interacting protein isoform 15 |
| NM_001368970.1 | NP_001355899.1 | muscular LMNA-interacting protein isoform 16 |
| NM_001368971.1 | NP_001355900.1 | muscular LMNA-interacting protein isoform 17 |
| NM_001368972.1 | NP_001355901.1 | muscular LMNA-interacting protein isoform 18 |
| NM_001368973.1 | NP_001355902.1 | muscular LMNA-interacting protein isoform 19 |
| NM_001368974.1 | NP_001355903.1 | muscular LMNA-interacting protein isoform 20 |
| NM_001368975.1 | NP_001355904.1 | muscular LMNA-interacting protein isoform 21 |
| NM_001368976.1 | NP_001355905.1 | muscular LMNA-interacting protein isoform 22 |
| NM_001368977.1 | NP_001355906.1 | muscular LMNA-interacting protein isoform 23 |
| NM_001368978.1 | NP_001355907.1 | muscular LMNA-interacting protein isoform 24 |
| NM_001368979.1 | NP_001355908.1 | muscular LMNA-interacting protein isoform 25 |
| NM_001368980.1 | NP_001355909.1 | muscular LMNA-interacting protein isoform 26 |
| NM_001368981.1 | NP_001355910.1 | muscular LMNA-interacting protein isoform 27 |
| NM_001368982.1 | NP_001355911.1 | muscular LMNA-interacting protein isoform 28 |
| NM_001368983.1 | NP_001355912.1 | muscular LMNA-interacting protein isoform 29 |
| NM_001368984.1 | NP_001355913.1 | muscular LMNA-interacting protein isoform 30 |
| NM_001368985.1 | NP_001355914.1 | muscular LMNA-interacting protein isoform 31 |
| NM_001368986.1 | NP_001355915.1 | muscular LMNA-interacting protein isoform 33 |
| NM_001368987.1 | NP_001355916.1 | muscular LMNA-interacting protein isoform 34 |
| NM_001368988.1 | NP_001355917.1 | muscular LMNA-interacting protein isoform 35 |
| NM_001368989.1 | NP_001355918.1 | muscular LMNA-interacting protein isoform 36 |
| NM_027150.1 | NP_081426.1 | muscular LMNA-interacting protein isoform 32 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables lamin binding |
IPI
IPI: Inferred from physical interaction
|
26436652 | MGI |
| enables transcription corepressor activity |
IGI
IGI: Inferred from genetic interaction
|
22343712 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within negative regulation of cardiac muscle hypertrophy |
IDA
IDA: Inferred from direct assay
|
22343712 | MGI |
| involved in negative regulation of cardiac muscle hypertrophy in response to stress |
IMP
IMP: Inferred from mutant phenotype
|
26359501 | MGI |
| acts upstream of or within negative regulation of transcription by RNA polymerase II |
IGI
IGI: Inferred from genetic interaction
|
22343712 | MGI |
| acts upstream of transcription by RNA polymerase II |
IGI
IGI: Inferred from genetic interaction
|
22343712 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in PML body |
IDA
IDA: Inferred from direct assay
|
21498514 | MGI |
| located in nuclear envelope |
IDA
IDA: Inferred from direct assay
|
21498514 | MGI |
| located in nuclear lumen |
IDA
IDA: Inferred from direct assay
|
21498514 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
22343712 | MGI |
| located in sarcolemma |
IDA
IDA: Inferred from direct assay
|
26359501 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
muscular LMNA-interacting protein |
|
Related Agents
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Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS08491 | MLIP Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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