2. Gene
  3. Mlip - muscular LMNA-interacting protein Gene

Mlip - muscular LMNA-interacting protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CIP; 2310046A06Rik

Gene ID: 69642 | Gene type: protein coding

About Mlip

Summary

Enables lamin binding activity and transcription corepressor activity. Involved in negative regulation of cardiac muscle hypertrophy in response to stress. Acts upstream of or within negative regulation of cardiac muscle hypertrophy and negative regulation of transcription by RNA polymerase II. Located in PML body; nuclear envelope; and sarcolemma. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Mlip Products(36)

mRNA Protein Name
NM_001368955.1 NP_001355884.1 muscular LMNA-interacting protein isoform 1
NM_001368956.1 NP_001355885.1 muscular LMNA-interacting protein isoform 2
NM_001368957.1 NP_001355886.1 muscular LMNA-interacting protein isoform 3
NM_001368958.1 NP_001355887.1 muscular LMNA-interacting protein isoform 4
NM_001368959.1 NP_001355888.1 muscular LMNA-interacting protein isoform 5
NM_001368960.1 NP_001355889.1 muscular LMNA-interacting protein isoform 6
NM_001368961.1 NP_001355890.1 muscular LMNA-interacting protein isoform 7
NM_001368962.1 NP_001355891.1 muscular LMNA-interacting protein isoform 8
NM_001368963.1 NP_001355892.1 muscular LMNA-interacting protein isoform 9
NM_001368964.1 NP_001355893.1 muscular LMNA-interacting protein isoform 10
NM_001368965.1 NP_001355894.1 muscular LMNA-interacting protein isoform 11
NM_001368966.1 NP_001355895.1 muscular LMNA-interacting protein isoform 12
NM_001368967.1 NP_001355896.1 muscular LMNA-interacting protein isoform 13
NM_001368968.1 NP_001355897.1 muscular LMNA-interacting protein isoform 14
NM_001368969.1 NP_001355898.1 muscular LMNA-interacting protein isoform 15
NM_001368970.1 NP_001355899.1 muscular LMNA-interacting protein isoform 16
NM_001368971.1 NP_001355900.1 muscular LMNA-interacting protein isoform 17
NM_001368972.1 NP_001355901.1 muscular LMNA-interacting protein isoform 18
NM_001368973.1 NP_001355902.1 muscular LMNA-interacting protein isoform 19
NM_001368974.1 NP_001355903.1 muscular LMNA-interacting protein isoform 20
NM_001368975.1 NP_001355904.1 muscular LMNA-interacting protein isoform 21
NM_001368976.1 NP_001355905.1 muscular LMNA-interacting protein isoform 22
NM_001368977.1 NP_001355906.1 muscular LMNA-interacting protein isoform 23
NM_001368978.1 NP_001355907.1 muscular LMNA-interacting protein isoform 24
NM_001368979.1 NP_001355908.1 muscular LMNA-interacting protein isoform 25
NM_001368980.1 NP_001355909.1 muscular LMNA-interacting protein isoform 26
NM_001368981.1 NP_001355910.1 muscular LMNA-interacting protein isoform 27
NM_001368982.1 NP_001355911.1 muscular LMNA-interacting protein isoform 28
NM_001368983.1 NP_001355912.1 muscular LMNA-interacting protein isoform 29
NM_001368984.1 NP_001355913.1 muscular LMNA-interacting protein isoform 30
NM_001368985.1 NP_001355914.1 muscular LMNA-interacting protein isoform 31
NM_001368986.1 NP_001355915.1 muscular LMNA-interacting protein isoform 33
NM_001368987.1 NP_001355916.1 muscular LMNA-interacting protein isoform 34
NM_001368988.1 NP_001355917.1 muscular LMNA-interacting protein isoform 35
NM_001368989.1 NP_001355918.1 muscular LMNA-interacting protein isoform 36
NM_027150.1 NP_081426.1 muscular LMNA-interacting protein isoform 32
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lamin binding IPI
IPI: Inferred from physical interaction
26436652 MGI
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
22343712 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
22343712 MGI
involved in negative regulation of cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
26359501 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22343712 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22343712 MGI
Cellular Component GO Annotation Evidence Reference Source
located in PML body IDA
IDA: Inferred from direct assay
21498514 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
21498514 MGI
located in nuclear lumen IDA
IDA: Inferred from direct assay
21498514 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22343712 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
26359501 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscular LMNA-interacting protein

cardiac Isl1-interacting protein

muscular-enriched A-type laminin-interacting protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08491 MLIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlip NCBI NCBI:90523