TRPC3 - transient receptor potential cation channel subfamily C member 3 Gene

Also Known as TRP3; SCA41

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7222

About TRPC3

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:121,874,481-121,952,060 (from NCBI)

This gene has 5 transcripts (splice variants), 160 orthologues, 5 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and Other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

TRPC3 Products (3)

mRNA	Protein	Name
NM_001130698.2	NP_001124170.1	short transient receptor potential channel 3 isoform a
NM_001366479.2	NP_001353408.1	short transient receptor potential channel 3 isoform e
NM_003305.2	NP_003296.1	short transient receptor potential channel 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	14505576	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10611319	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	21062895	GOA
involved in positive regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	21062895	GOA
involved in positive regulation of cardiac muscle hypertrophy in response to stress	IDA IDA: Inferred from direct assay	19287093	GOA
involved in response to ATP	IDA IDA: Inferred from direct assay	21062895	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	21062895	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	9368034	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC3 Protein Structure

Ank_2

TRP_2

Ion_trans

0
200
400
600
800
921 a.a.

Protein Preferred Names	Protein Names
short transient receptor potential channel 3	hTrp-3

TRPC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRPC3	Q13507	ORAI1	Homo sapiens	Q96D31	Anti Tag CoIP	17360584
Intra	TRPC3	Q13507	ORAI1	Homo sapiens	Q96D31	Pull Down	17360584
Intra	TRPC3	Q13507	ITPR3	Homo sapiens	Q14573	Anti Bait CoIP	10611319
Intra	TRPC3	Q13507	ITPR3	Homo sapiens	Q14573	Pull Down	10611319
Intra	TRPC3	Q13507	MX1	Homo sapiens	P20591	Pull Down	15757897
Intra	TRPC3	Q13507	MX1	Homo sapiens	P20591	Anti Tag CoIP	15757897
Cross	TRPC3	Q13507	Plcg1	Rattus norvegicus	P10686	Pull Down	15744307

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 41	Spinocerebellar Ataxia Type 41 SCA41 Ataxia, Spinocerebellar, Type 41
Spinocerebellar Ataxia 14	Spinocerebellar Ataxia Type 14 SCA14 Ataxia, Spinocerebellar, Type 14
Cerebellar Ataxia Type 41	Sca41
Immunodeficiency 10	Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2 Combined Immunodeficiency Due To Stim1 Deficiency IMD10 Stim1 Deficiency Cid Due To Stim1 Deficiency Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2 Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Progressive Familial Heart Block	Hereditary Bundle Branch Defect Hereditary Bundle Branch System Defect Familial Lenegre Disease Familial Lev Disease Familial Lev-Lenegre Disease Familial Pccd Familial Progressive Heart Block Pfhb Bundle Branch Block Hbbd Lenegre Lev Disease Lev Syndrome Lev'S Disease Lev-Lenègre Disease Pccd Progressive Cardiac Conduction Defect Bundle-Branch Block
Sialolithiasis	Sialolith Stone Of Salivary Gland Or Duct Salivary Gland Calculi Salivary Gland Stone Calculus Of Salivary Gland Or Duct Calculus Of Salivary Gland Salivary Calculus Salivary Gland Calculus Salivary Stone Salivary Duct Calculi Sialodocholithiasis
Mucolipidosis Iv	Mucolipidosis Type Iv ML4 Sialolipidosis Mucolipidosis Type 4 Ganglioside Sialidase Deficiency Mliv Ml Iv Berman Syndrome Ganglioside Neuraminidase Deficiency Ml 4 Mucolipidosis 4 Type Iv Mucolipidosis Gangliosidoses
Stormorken Syndrome	Thrombocytopathy, Asplenia, And Miosis Stormorken-Sjaastad-Langslet Syndrome STRMK York Platelet Syndrome Yps Thrombocytopathy, Asplenia And Miosis Thrombocytopathy Asplenia Miosis Thrombocytopathy-Asplenia-Miosis Syndrome Miosis Disorder
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Malignant Hyperthermia	Anesthesia Related Hyperthermia Malignant Hyperpyrexia Due To Anesthesia Hyperpyrexia, Malignant Hyperthermia, Malignant Malignant Hyperpyrexia Mhs Malignant Fever
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111098	GSK1702934A	Agonist	99.52%	Unkown
HY-19408	Pyr10	Inhibitor	99.95%	Unkown
HY-101795	Larixyl acetate	Inhibitor	99.44%	Unkown
HY-133012	GFB-8438	Inhibitor	99.74%	Unkown
HY-108464A	Phenamil methanesulfonate	Inhibitor	98.1%	Unkown
HY-161766	L687	Activator	99.49%	Unkown
HY-138668	JW-65	Inhibitor	99.05%	Unkown
HY-147357	TRPC3/6-IN-1	Inhibitor	99.20%	Unkown
HY-179489	TRPC3 agonist-1	Agonist	/	Unkown
HY-162090	TRPC antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRPC3	VGNC	VGNC:47867
Macaca mulatta	TRPC3	VGNC	VGNC:78652
Bos taurus	TRPC3	VGNC	VGNC:36382
Mus musculus	TRPC3	MGD	MGI:109526
Rattus norvegicus	TRPC3	RGD	RGD:61973
Felis catus	TRPC3	VGNC	VGNC:66582
Others	TRPC3	NCBI