TRPC antagonist 1
TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines.
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- No. CAS: 3027139-12-1
- Fòrmula: C23H22N4O2S
- Peso molecular:418.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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TRPC3 2.4 μM (IC50) |
TRPC4 12.2 μM (IC50) |
TRPC5 7.6 μM (IC50) |
TRPC6 2.9 μM (IC50) |
TRPC7 3.4 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
21.1 μM
Compound: 15g
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| HCT-116 | IC50 |
9.8 μM
Compound: 15g
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| LNCaP | IC50 |
8.3 μM
Compound: 15g
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Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| MKN-45 | IC50 |
11 μM
Compound: 15g
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Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| U-87MG ATCC | IC50 |
5.7 μM
Compound: 15g
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Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
Chemical Information
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No. CAS 3027139-12-1
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Peso molecular 418.51
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Fòrmula C23H22N4O2S
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SMILES
NCCN(C1=NC(C(NC2=CC=C(O)C=C2)=O)=CS1)CC3=CC=C(C=CC=C4)C4=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPC antagonist 1 Related Classifications
HY-162090 Related Classifications
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