TRPC antagonist 1
TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines.
For research use only. We do not sell to patients.
- CAS No.: 3027139-12-1
- Formula: C23H22N4O2S
- Molecular Weight:418.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TRPC3 2.4 μM (IC50) |
TRPC4 12.2 μM (IC50) |
TRPC5 7.6 μM (IC50) |
TRPC6 2.9 μM (IC50) |
TRPC7 3.4 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
21.1 μM
Compound: 15g
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| HCT-116 | IC50 |
9.8 μM
Compound: 15g
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| LNCaP | IC50 |
8.3 μM
Compound: 15g
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Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| MKN-45 | IC50 |
11 μM
Compound: 15g
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Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
| U-87MG ATCC | IC50 |
5.7 μM
Compound: 15g
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Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38185057] |
Chemical Information
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CAS No. 3027139-12-1
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Molecular Weight 418.51
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Formula C23H22N4O2S
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SMILES
NCCN(C1=NC(C(NC2=CC=C(O)C=C2)=O)=CS1)CC3=CC=C(C=CC=C4)C4=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPC antagonist 1 Related Classifications
HY-162090 Related Classifications
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