2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPC antagonist 1

TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines.

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TRPC antagonist 1

TRPC antagonist 1 Chemical Structure

CAS No. : 3027139-12-1

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TRPC antagonist 1 Related Antibodies

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TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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Description

TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines[1].

IC50 & Target[1]

TRPC3

2.4 μM (IC50)

TRPC4

12.2 μM (IC50)

TRPC5

7.6 μM (IC50)

TRPC6

2.9 μM (IC50)

TRPC7

3.4 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
21.1 μM
Compound: 15g
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
HCT-116 IC50
9.8 μM
Compound: 15g
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
LNCaP IC50
8.3 μM
Compound: 15g
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
MKN-45 IC50
11 μM
Compound: 15g
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
U-87MG ATCC IC50
5.7 μM
Compound: 15g
Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
Molecular Weight

418.51

Formula

C23H22N4O2S
CAS No.
SMILES

NCCN(C1=NC(C(NC2=CC=C(O)C=C2)=O)=CS1)CC3=CC=C(C=CC=C4)C4=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRPC antagonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPC antagonist 13027139-12-1TRPC antagonist1TRPC antagonist-1TRP ChannelTransient receptor potential channelsTRPC antagonistanti-glioblastoma agentTRPC3TRPC4TRPC5TPRC6and TRPC7Inhibitorinhibitorinhibit

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