3027139-12-1
3027139-12-1
Chemical Structure
TRPC antagonist 1
- CAS No.: 3027139-12-1
- Formula:C23H22N4O2S
- Molecular Weight:418.51
InChIKey: UKTIJZJOHLGMQZ-UHFFFAOYSA-N
SMILES: NCCN(C1=NC(C(NC2=CC=C(O)C=C2)=O)=CS1)CC3=CC=C(C=CC=C4)C4=C3
Biological Activity: TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines[1].
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TRPC antagonist 1 | TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines. | |||||||||||||||||||||
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References
Keywords
