Plcg1 - phospholipase C, gamma 1 Gene

Also Known as PPLCA

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25738

Summary

Enables Insulin Receptor binding activity; Phospholipase C activity; and phosphoprotein binding activity. Involved in several processes, including inositol trisphosphate biosynthetic process; regulation of store-operated Calcium Channel activity; and response to morphine. Located in clathrin-coated vesicle. Colocalizes with neuron projection. Orthologous to human PLCG1 (Phospholipase C gamma 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcg1 Products (1)

mRNA	Protein	Name
NM_013187.2	NP_037319.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent phospholipase C activity	IDA IDA: Inferred from direct assay	7531435	RGD
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	15252117	RGD
enables insulin receptor binding	IDA IDA: Inferred from direct assay	14568990	RGD
enables phosphatidylinositol phospholipase C activity	IDA IDA: Inferred from direct assay	7531435	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	8910399	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10077576	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion transport	IMP IMP: Inferred from mutant phenotype	12437926	RGD
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	7531435	RGD
involved in inositol trisphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	16973916	RGD
involved in inositol trisphosphate metabolic process	IDA IDA: Inferred from direct assay	7812955	RGD
involved in phosphatidylinositol catabolic process	IDA IDA: Inferred from direct assay	7812955	RGD
involved in phosphatidylinositol metabolic process	IDA IDA: Inferred from direct assay	7531435	RGD
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	16973916	RGD
involved in regulation of store-operated calcium channel activity	IMP IMP: Inferred from mutant phenotype	17432954	RGD
involved in response to curcumin	IDA IDA: Inferred from direct assay	7812955	RGD
involved in response to gravity	IEP IEP: Inferred from expression pattern	17404041	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17982259	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	11779129	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLC-148 PLC-II PLC-gamma-1 phosphoinositide phospholipase C phosphoinositide phospholipase C-gamma-1

Plcg1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Plcg1	P10686	FGFR1	Homo sapiens	P11362	X-Ray Diffraction	19665973
Intra	Plcg1	P10686	Fgfr1	Rattus norvegicus	Q04589	ITC	19665973
Cross	Plcg1	P10686	TRPC3	Homo sapiens	Q13507	Y2H	15744307
Cross	Plcg1	P10686	Jak2	Mus musculus	Q62120	IF	17128263
Cross	Plcg1	P10686	Jak2	Mus musculus	Q62120	Anti Tag CoIP	17128263
Cross	Plcg1	P10686	Khdrbs2	Mus musculus	Q9WU01	Pull Down	10077576
Cross	Plcg1	P10686	PTPN1	Homo sapiens	P18031	Anti Tag CoIP	17128263
Cross	Plcg1	P10686	PTPN1	Homo sapiens	P18031	IF	17128263

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10660	PLCG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19470	Plcg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25963	Plcg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plcg1	NCBI	NCBI:5335