Khdrbs2 - KH domain containing, RNA binding, signal transduction associated 2 Gene

Also Known as Slm1; Slim1; Slm-1; mSLM-1; TG-RP135; 6330586C16Rik; Tg(LRRK2*R1441G)135Cjli

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170771

Summary

The protein encoded by this gene is similar to the Src associated in Mitosis, 68 kDa protein, which is an RNA-binding protein and a substrate for Src-family tyrosine kinases during Mitosis. This protein has a KH RNA-binding motif and proline-rich motifs which may be SH2 and SH3 domain binding sites. A similar rat protein is an RNA-binding protein which is tyrosine phosphorylated by Src during Mitosis. These studies also suggest that the rat protein may function as an adaptor protein for Src by binding the SH2 and SH3 domains of various Other proteins. [provided by RefSeq, Jul 2008]

Khdrbs2 Products (1)

mRNA Protein Name
NM_133235.3 NP_573498.1 KH domain-containing, RNA-binding, signal transduction-associated protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
10077576 MGI
enables SH3 domain binding IDA
IDA: Inferred from direct assay
10077576 MGI
enables poly(A) binding IDA
IDA: Inferred from direct assay
10077576 MGI
enables poly(U) RNA binding IDA
IDA: Inferred from direct assay
10077576 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10077576 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
22196734 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

KH domain-containing, RNA-binding, signal transduction-associated protein 2

  • LRRK2

  • Sam68-like mammalian protein 1

Khdrbs2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Khdrbs2 Q9WU01 Plcg1 Rattus norvegicus P10686
Pull Down
10077576
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07238 KHDRBS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Khdrbs2 NCBI NCBI:202559