CASP5 - caspase 5 Gene

Also Known as ICH-3; ICEREL-III; ICE(rel)III

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 838

About CASP5

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:104,994,243-105,023,168 (from NCBI)

This gene has 9 transcripts (splice variants), 420 orthologues and 16 paralogues. Biased expression in appendix (RPKM 4.9), small intestine (RPKM 4.7) and 5 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces Apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and Apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

CASP5 Products (6)

mRNA Protein Name
NM_001136109.3 NP_001129581.1 caspase-5 isoform b
NR_036562.3
NM_001136110.3 NP_001129582.1 caspase-5 isoform c
NR_024239.3
NM_004347.5 NP_004338.3 caspase-5 isoform a precursor
NM_001136112.3 NP_001129584.1 caspase-5 isoform f

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
16920334 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30692621 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19593445 GOA
involved in protein maturation IDA
IDA: Inferred from direct assay
37993714 GOA
Cellular Component GO Annotation Evidence References Source
part of NLRP1 inflammasome complex IDA
IDA: Inferred from direct assay
12191486 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP5 Protein Structure

CARD

CARD: Caspase recruitment domain (62 - 140)

Peptidase_C14

Peptidase_C14: Caspase domain (193 - 429)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 434 a.a.
Protein Preferred Names Protein Names

caspase-5

  • TY protease

  • caspase 5, apoptosis-related cysteine peptidase

  • caspase 5, apoptosis-related cysteine protease

  • protease ICH-3

  • protease TY

CASP5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81252 Caspase-5 p20 Antibody WB, IHC-P, IHC-F, ICC/IF, ELISA Human, Mouse

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Cowpox

  • Yaba
Lynch Syndrome

  • Hereditary Nonpolyposis Colon Cancer

  • Hereditary Nonpolyposis Colorectal Cancer

  • Hereditary Nonpolyposis Colorectal Carcinoma

  • Hereditary Nonpolyposis Colorectal Neoplasms

  • Familial Nonpolyposis Colon Cancer

  • Hnpcc

  • Coca 1

  • Hereditary Defective Mismatch Repair Syndrome

  • Hereditary Non-Polyposis Colon Cancer

  • Hereditary Non-Polyposis Colon Cancer Syndrome

  • Hereditary Non-Polyposis Colorectal Cancer

  • Hereditary Non-Polyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colon Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Neoplasm

  • Hnpcc - Hereditary Nonpolyposis Colon Cancer

  • Cancer Family Syndrome

  • Familial Nonpolyposis Colorectal Cancer

  • Colon Cancer, Familial Nonpolyposis

  • Colorectal Neoplasms, Hereditary Nonpolyposis

  • Cancer, Colorectal, Nonpolyposis, Hereditary

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Familial Mediterranean Fever

  • FMF

  • Benign Paroxysmal Peritonitis

  • Periodic Disease

  • Periodic Fever Syndrome

  • Recurrent Polyserositis

  • Familial Paroxysmal Polyserositis

  • Periodic Fever

  • Familial Mediterranean Fever, Autosomal Recessive

  • Familial Mediterranean Fever, Ar

  • Polyserositis, Recurrent

  • Polyserositis, Familial Paroxysmal

  • Periodic Peritonitis

  • Mef

  • Reimann Periodic Disease

  • Siegal-Cattan-Mamou Disease

  • Wolff Periodic Disease

  • Benign Recurrent Polyserositis

  • Mediterranean Fever, Familial

  • ARFMF

  • Autosomal Recessive Familial Mediterranean Fever

  • Fever, Mediterranean, Familial, Autosomal Recessive

  • Hereditary Autoinflammatory Diseases

  • Fmf - [Familial Mediterranean Fever]

  • Periodic Polyserositis

  • Periodic Familial Polyserositis

  • Periodic Familial Peritonitis

  • Paroxysmal Polyserositis

  • Hereditary Amyloid Nephropathy

  • Familial Recurrent Polyserositis

  • Familial Non-Neuropathic Amyloidosis

  • Armenian Disease

  • Riemann Periodic Disease

  • Siegal Cattan Mamou Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01958 CASP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CASP5 MGD MGI:107700
Macaca mulatta CASP5 VGNC VGNC:70544
Others CASP5 NCBI