CASP5 - caspase 5 Gene

Homo sapiens

Also known as ICH-3; ICEREL-III; ICE(rel)III

Gene ID: 838 | Gene type: protein coding

About CASP5

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:104,994,243-105,023,168 (from NCBI)

This gene has 9 transcripts (splice variants), 420 orthologues and 16 paralogues. Biased expression in appendix (RPKM 4.9), small intestine (RPKM 4.7) and 5 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active Enzyme. Overexpression of the active form of this Enzyme induces Apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and Apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

CASP5 Products(6)

mRNA	Protein	Name
NM_001136109.3	NP_001129581.1	caspase-5 isoform b
NR_036562.3
NM_001136110.3	NP_001129582.1	caspase-5 isoform c
NR_024239.3
NM_004347.5	NP_004338.3	caspase-5 isoform a precursor
NM_001136112.3	NP_001129584.1	caspase-5 isoform f

CASP5 Protein Structure

CARD

Peptidase_C14

0
100
200
300
400
434 a.a.

Protein Preferred Names

Protein Names

caspase-5

TY protease	caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine protease	protease ICH-3
protease TY

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Cowpox

Yaba

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Familial Mediterranean Fever

FMF	Benign Paroxysmal Peritonitis
Periodic Disease	Periodic Fever Syndrome
Recurrent Polyserositis	Familial Paroxysmal Polyserositis
Periodic Fever	Familial Mediterranean Fever, Autosomal Recessive
Familial Mediterranean Fever, Ar	Polyserositis, Recurrent
Polyserositis, Familial Paroxysmal	Periodic Peritonitis
Mef	Reimann Periodic Disease
Siegal-Cattan-Mamou Disease	Wolff Periodic Disease
Benign Recurrent Polyserositis	Mediterranean Fever, Familial
ARFMF	Autosomal Recessive Familial Mediterranean Fever
Fever, Mediterranean, Familial, Autosomal Recessive	Hereditary Autoinflammatory Diseases
Fmf - [Familial Mediterranean Fever]	Periodic Polyserositis
Periodic Familial Polyserositis	Periodic Familial Peritonitis
Paroxysmal Polyserositis	Hereditary Amyloid Nephropathy
Familial Recurrent Polyserositis	Familial Non-Neuropathic Amyloidosis
Armenian Disease	Riemann Periodic Disease
Siegal Cattan Mamou Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01958	CASP5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CASP5	MGD	MGI:107700
Macaca mulatta	CASP5	VGNC	VGNC:70544

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