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RBM17 - RNA binding motif protein 17 Gene

Also Known as SPF45

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84991

About RBM17

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:6,089,034-6,117,447 (from NCBI)

This gene has 12 transcripts (splice variants) and 225 orthologues. Ubiquitous expression in bone marrow (RPKM 17.7), lymph node (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]

RBM17 Products (2)

mRNA	Protein	Name
NM_001145547.2	NP_001139019.1	splicing factor 45
NM_032905.5	NP_116294.1	splicing factor 45

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	17589525	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM17 Protein Structure

G-patch

RRM_5

0
100
200
300
401 a.a.

Protein Preferred Names	Protein Names
splicing factor 45	45 kDa-splicing factor

RBM17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBM17	Q96I25	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	RBM17	Q96I25	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	RBM17	Q96I25	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	RBM17	Q96I25	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	RBM17	Q96I25	PPP1R12C	Homo sapiens	Q9BZL4-5	Y2H Prey Pooling	25416956
Intra	RBM17	Q96I25	PPP1R12C	Homo sapiens	Q9BZL4-5	Y2H Array	25416956
Intra	RBM17	Q96I25	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	RBM17	Q96I25	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	RBM17	Q96I25	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	RBM17	Q96I25	SF1	Homo sapiens	Q15637-4	Y2H Array	32296183
Intra	RBM17	Q96I25	SF1	Homo sapiens	Q15637-4	Y2H Prey Pooling	32296183
Intra	RBM17	Q96I25	DHX15	Homo sapiens	O43143	Anti Tag CoIP	35271311
Intra	RBM17	Q96I25	DHX15	Homo sapiens	O43143	Validated Y2H	25416956
Intra	RBM17	Q96I25	DHX15	Homo sapiens	O43143	Y2H Array	25416956
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533-1	X-Ray Diffraction	17589525
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533-1	Pull Down	17589525
Intra	RBM17	Q96I25	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	RBM17	Q96I25	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	RBM17	Q96I25	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	28514442
Intra	RBM17	Q96I25	SUGP1	Homo sapiens	Q8IWZ8	Anti Tag CoIP	35271311
Intra	RBM17	Q96I25	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	25416956
Intra	RBM17	Q96I25	QRICH1	Homo sapiens	Q2TAL8	Y2H Prey Pooling	25416956
Intra	RBM17	Q96I25	CCDC170	Homo sapiens	Q8IYT3	Y2H Array	32296183
Intra	RBM17	Q96I25	CCDC170	Homo sapiens	Q8IYT3	Y2H Prey Pooling	32296183
Intra	RBM17	Q96I25	U2SURP	Homo sapiens	O15042	Anti Tag CoIP	33961781
Intra	RBM17	Q96I25	U2SURP	Homo sapiens	O15042	Anti Tag CoIP	35271311
Intra	RBM17	Q96I25	U2SURP	Homo sapiens	O15042	Y2H	22365833
Intra	RBM17	Q96I25	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	RBM17	Q96I25	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RBM17	Q96I25	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RBM17	Q96I25	SAT1	Homo sapiens	P21673	Y2H	21516116
Intra	RBM17	Q96I25	SAT1	Homo sapiens	P21673	Validated Y2H	25416956
Intra	RBM17	Q96I25	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	RBM17	Q96I25	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	RBM17	Q96I25	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	RBM17	Q96I25	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	RBM17	Q96I25	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	RBM17	Q96I25	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RBM17	Q96I25	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	RBM17	Q96I25	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RBM17	Q96I25	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Prey Pooling	32296183
Intra	RBM17	Q96I25	PPP1R12C	Homo sapiens	Q9BZL4	Validated Y2H	32296183
Intra	RBM17	Q96I25	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Array	32296183
Intra	RBM17	Q96I25	U2AF2	Homo sapiens	P26368	Pull Down	17589525
Intra	RBM17	Q96I25	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826
Intra	RBM17	Q96I25	SF1	Homo sapiens	Q15637	Pull Down	17589525
Intra	RBM17	Q96I25	IQCN	Homo sapiens	Q9H0B3	Y2H Prey Pooling	25416956
Intra	RBM17	Q96I25	IQCN	Homo sapiens	Q9H0B3	Y2H Array	25416956
Intra	RBM17	Q96I25	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	RBM17	Q96I25	CEP55	Homo sapiens	Q53EZ4	Y2H Array	31515488
Intra	RBM17	Q96I25	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533	Anti Tag CoIP	33961781
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533	Anti Tag CoIP	28514442
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533	Anti Tag CoIP	35271311
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533	Phage Display	37219487
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533	Anti Tag CoIP	22365833
Intra	RBM17	Q96I25	SF3B1	Homo sapiens	O75533	Y2H	22365833
Intra	RBM17	Q96I25	ATXN1	Homo sapiens	P54253	Anti Tag CoIP	18337722
Intra	RBM17	Q96I25	ATXN1	Homo sapiens	P54253	Y2H	18337722

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Spinocerebellar Ataxia 1	Spinocerebellar Ataxia Type 1 SCA1 Olivopontocerebellar Atrophy I Opca1 Opca4 Menzel Type Opca Schut-Haymaker Type Opca Spinocerebellar Atrophy I Opca I Olivopontocerebellar Atrophy Iv Opca Iv Cerebelloparenchymal Disorder I Cpd1 Olivopontocerebellar Atrophy 1 Cerebelloparenchymal Disorder 1 Olivopontocerebellar Atrophy 4 Spinocerebellar Atrophy 1 Type 1 Spinocerebellar Ataxia Spinocerebellar Ataxia-1 Ataxia, Spinocerebellar, Type 1
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11737	RBM17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RBM17	VGNC	VGNC:45411
Mus musculus	RBM17	MGD	MGI:1924188
Bos taurus	RBM17	VGNC	VGNC:33788
Macaca mulatta	RBM17	VGNC	VGNC:76496
Rattus norvegicus	RBM17	RGD	RGD:1311208
Felis catus	RBM17	VGNC	VGNC:64522
Others	RBM17	NCBI