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CCN5 - cellular communication network factor 5 Gene

Also Known as CT58; WISP2; CTGF-L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8839

About CCN5

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,714,861-44,727,811 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 5 paralogues. Biased expression in ovary (RPKM 59.2), fat (RPKM 22.7) and 9 other tissues.

Summary

This gene encodes a member of the Wnt1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. Wnt1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the Wnt1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the Other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

CCN5 Products (3)

mRNA	Protein	Name
NM_001323369.2	NP_001310298.1	CCN family member 5 isoform 2 precursor
NM_001323370.2	NP_001310299.1	CCN family member 5 isoform 1 precursor
NM_003881.4	NP_003872.1	CCN family member 5 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10358067	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20531984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCN5 Protein Structure

IGFBP

VWC

TSP_1

0
100
200
250 a.a.

Protein Preferred Names	Protein Names
CCN family member 5	WNT1 inducible signaling pathway protein 2

CCN5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCN5	O76076	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	CCN5	O76076	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	CCN5	O76076	HOXA1	Homo sapiens	P49639	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Wilms Tumor 5	Wilms Tumor WT5 Wilms Tumor Susceptibility-5 Wilms Tumor And Radial Bilateral Aplasia Nephroblastoma Wilms' Tumor Wilms Tumor, Susceptibility To Wtsl Bilateral Radial Aplasia With Wilms Tumor Embryonal Adenosarcoma Embryonal Nephroma Kidney Wilms Tumor Kidney, Adenomyosarcoma, Embryonal Kidney, Carcinosarcoma, Embryonal Kidney, Embryoma Kidney, Embryonal Mixed Tumor Nephroma Renal Adenosarcoma Renal Cancer, Wilms Renal Wilms Tumor Tumor, Wilms Hereditary Susceptibility To Wilms Tumor 5
Acth-Independent Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenocortical Hyperplasia Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia Corticotropin-Independent Macronodular Adrenal Hyperplasia Cushing Syndrome Due To Macronodular Adrenal Hyperplasia AIMAH1 Aimah Massive Macronodular Adrenocortical Disease Mmad Primary Macronodular Adrenal Hyperplasia Cushing Syndrome, Adrenal, Due To Aimah Primary Bilateral Macronodular Adrenal Hyperplasia Acth-Independent Macronodular Adrenal Hyperplasia 1 Acth-Independent Cushing Syndrome Adrenal Cushing Syndrome Due To Aimah Acth-Independent Macronodular Adrenal Hyperplasia 2
Bladder Transitional Cell Papilloma	Bladder Papilloma Transitional Cell Papilloma Of Bladder Urinary Bladder Urothelial Papilloma Urothelial Papilloma Bladder Urothelial Papilloma
Primary Pigmented Nodular Adrenocortical Disease	Ppnad Primary Pigmented Nodular Adrenal Dysplasia Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 1
Bladder Papillary Transitional Cell Neoplasm	Urinary Bladder Papillary Urothelial Neoplasm Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm	Inverted Papilloma Of Urinary Tract Papillary Transitional Cell Neoplasm Of The Urinary Tract Urinary Tract Inverted Papilloma Inverted Urothelial Papilloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02114	CCN5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21304	Ccn5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27823	Ccn5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCN5	RGD	RGD:621867
Felis catus	CCN5	VGNC	VGNC:60548
Mus musculus	CCN5	MGD	MGI:1328326
Macaca mulatta	CCN5	VGNC	VGNC:84569
Canis familiaris	CCN5	VGNC	VGNC:48415
Bos taurus	CCN5	VGNC	VGNC:36945
Others	CCN5	NCBI