CLDN10 - claudin 10 Gene

Homo sapiens

Also known as OSPL; HELIX; OSP-L; CPETRL3

Gene ID: 9071 | Gene type: protein coding

About CLDN10

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:95,433,755-95,579,759 (from NCBI)

This gene has 3 transcripts (splice variants), 419 orthologues, 22 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues.

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]

CLDN10 Products(3)

mRNA	Protein	Name
NM_001160100.2	NP_001153572.1	claudin-10 isoform a_i1
NM_006984.5	NP_008915.1	claudin-10 isoform b precursor
NM_182848.4	NP_878268.1	claudin-10 isoform a

CLDN10 Protein Structure

PMP22_Claudin

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

claudin-10

OSP-like protein

Related Diseases

Diseases

Alias

Helix Syndrome

HELIX	Hypohidrosis, Electrolyte Imbalance, Lacrimal Gland Dysfunction, Ichthyosis, And Xerostomia
Hypohidrosis-Electrolyte Imbalance-Lacrimal Gland Dysfunction-Ichthyosis-Xerostomia Syndrome

Anhidrosis

Hypohidrosis	Absence Of Sweating
Adiaphoresis	Impaired Sweating
Oligohidrosis

Adenocarcinoma In Situ

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Deafness, Autosomal Recessive 29

DFNB29	Autosomal Recessive Nonsyndromic Deafness 29
Autosomal Recessive Deafness 29	Deafness, Autosomal Recessive, 29
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29
Deafness, Autosomal Recessive, Type 29

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02763	CLDN10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CLDN10	VGNC	VGNC:39309
Bos taurus	CLDN10	VGNC	VGNC:27403
Macaca mulatta	CLDN10	VGNC	VGNC:71243
Rattus norvegicus	CLDN10	RGD	RGD:1308027
Mus musculus	CLDN10	MGD	MGI:1913101
Felis catus	CLDN10	VGNC	VGNC:102180

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