CLDN10 - claudin 10 Gene

Also Known as OSPL; HELIX; OSP-L; CPETRL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9071

About CLDN10

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:95,433,755-95,579,759 (from NCBI)

This gene has 3 transcripts (splice variants), 419 orthologues, 22 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues.

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]

CLDN10 Products (3)

mRNA Protein Name
NM_001160100.2 NP_001153572.1 claudin-10 isoform a_i1
NM_006984.5 NP_008915.1 claudin-10 isoform b precursor
NM_182848.4 NP_878268.1 claudin-10 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
28028216 GOA
enables paracellular tight junction channel activity IDA
IDA: Inferred from direct assay
19383724 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in paracellular transport IDA
IDA: Inferred from direct assay
19383724 GOA
involved in regulation of monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
28686597 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
28771254 GOA
located in tight junction IDA
IDA: Inferred from direct assay
19383724 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN10 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (6 - 179)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

claudin-10

  • OSP-like protein

CLDN10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLDN10 P78369 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
CLDN10 P78369 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
CLDN10 P78369 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
CLDN10 P78369 REEP1 Homo sapiens Q9H902
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 REEP1 Homo sapiens Q9H902
Y2H Array
32296183
Intra
CLDN10 P78369 REEP1 Homo sapiens Q9H902
Validated Y2H
32296183
Intra
CLDN10 P78369 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
CLDN10 P78369 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
CLDN10 P78369 BEST2 Homo sapiens Q8NFU1
Validated Y2H
32296183
Intra
CLDN10 P78369 BEST2 Homo sapiens Q8NFU1
Y2H Array
32296183
Intra
CLDN10 P78369 BEST2 Homo sapiens Q8NFU1
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
CLDN10 P78369 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 TMEM9 Homo sapiens Q9P0T7
Validated Y2H
32296183
Intra
CLDN10 P78369 TMEM9 Homo sapiens Q9P0T7
Y2H Array
32296183
Intra
CLDN10 P78369 TMEM9 Homo sapiens Q9P0T7
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
CLDN10 P78369 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CLDN10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810955 Claudin 10 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Helix Syndrome

  • HELIX

  • Hypohidrosis, Electrolyte Imbalance, Lacrimal Gland Dysfunction, Ichthyosis, And Xerostomia

  • Hypohidrosis-Electrolyte Imbalance-Lacrimal Gland Dysfunction-Ichthyosis-Xerostomia Syndrome
Anhidrosis

  • Hypohidrosis

  • Absence Of Sweating

  • Adiaphoresis

  • Impaired Sweating

  • Oligohidrosis
Adenocarcinoma In Situ
Endometrial Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Endometrium

  • Adenosquamous Carcinoma Of The Endometrium

  • Endometrial Adenosquamous Cancer

  • Endometrial Adenosquamous Cell Carcinoma
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Ichthyosis

  • Ichthyoses

  • Non-Syndromic Ichthyosis

  • Congenital Ichthyosis
Deafness, Autosomal Recessive 29

  • DFNB29

  • Autosomal Recessive Nonsyndromic Deafness 29

  • Autosomal Recessive Deafness 29

  • Deafness, Autosomal Recessive, 29

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29

  • Deafness, Autosomal Recessive, Type 29
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02763 CLDN10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLDN10 VGNC VGNC:39309
Bos taurus CLDN10 VGNC VGNC:27403
Macaca mulatta CLDN10 VGNC VGNC:71243
Rattus norvegicus CLDN10 RGD RGD:1308027
Mus musculus CLDN10 MGD MGI:1913101
Felis catus CLDN10 VGNC VGNC:102180
Others CLDN10 NCBI