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Cat. No.: HY-181127

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GluN2B-NMDAR Allosteric modulator 1

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GluN2B-NMDAR Allosteric modulator 1 is a selective GluN2B-NMDAR positive allosteric modulator. GluN2B-NMDAR Allosteric modulator 1 can increase glutamate- and aspartate-evoked GluN2B-NMDAR-gated currents with EC₅₀ values of 43.7 and 18 nM. GluN2B-NMDAR Allosteric modulator 1 can reverse anxiety-like behavior and social cognition deficits in mice. GluN2B-NMDAR Allosteric modulator 1 can be used for the research of neurological disease, such as anxiety.

For research use only. We do not sell to patients.

Purity: 99.87%
CAS No.: 2419700-58-4
Formula: C₁₇H₂₁N₅
Molecular Weight:295.38

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

GluN2B-NMDAR Allosteric modulator 1 Chemical Structure

CAS No.: 2419700-58-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GluN2B

All iGluR Isoforms :

In Vitro

GluN2B-NMDAR Allosteric modulator 1 (Compound 175) (0.001-100 μM) increases glutamate-evoked GluN1/GluN2B-NMDAR-gated currents in HEK293 cells with an EC₅₀ of 43.7 nM (logEC₅₀ = -7.36)^[1].
GluN2B-NMDAR Allosteric modulator 1 (0.0001-1 μM) dose-dependently and selectively potentiates aspartate-evoked GluN2B-containing native NMDAR currents in primary rat hippocampal neurons with an EC₅₀ of 18 nM^[1].
GluN2B-NMDAR Allosteric modulator 1 (1 μM; 3 h) does not induce cytotoxicity in primary cortical neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GluN2B-NMDAR Allosteric modulator 1 (Compound 175) (1 mg/kg; i.p.; 30 min before the induction of synaptic plasticit) facilitates low-frequency stimulation-induced long-term depression via a GluN2B-containing NMDAR-dependent mechanism in anesthetized rats^[1].
GluN2B-NMDAR Allosteric modulator 1 (1 mg/kg; i.p.; single dose) reverses anxiety-like behavior and social cognition deficits in 7-month-old Mecp2-OE mice and in a transgenic mouse line harboring an inducible expression of Disc1-N mice.^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mecp2-OE mice (7 months old); a transgenic mouse line harboring an inducible expression of Disc1-N mice (C57BL/6; 3-4 months old) ^[1]
Dosage:

1 mg/kg
Administration:

I.p.; single dose (30 minutes before each behavioral test)
Result:

Restored center time in the open-field test to WT levels (reversing anxiety-like behavior) and significantly improved social preference index in Mecp2-OE mice.
Increased time spent in the center of the open-field test (reversing anxiety-like behavior), increased spontaneous alternation in the Y-maze test (improving spatial working memory) and increased social preference index in the three-chamber test (reversing sociability deficit) in Disc1-N mice.

Chemical Information

CAS No. 2419700-58-4
Appearance Oil
Molecular Weight 295.38
Formula C₁₇H₂₁N₅
Color Light yellow to yellow
SMILES

CC(N1C=CN=C1CNCC2=CC=C(N3C=CN=C3)C=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ge Y, et al. GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and behavioral abnormalities in Mecp2 and Disc1 transgenic mice. Sci Adv. 2026 Jan 9;12(2):eady3891. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

GluN2B-NMDAR Allosteric modulator 1

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Biological Activity
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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GluN2B-NMDAR Allosteric modulator 1

Neurotransmitter Receptor Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Allosteric Modulators (AMs) Compound Library

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MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

All iGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GluN2B-NMDAR Allosteric modulator 1

Neurotransmitter Receptor Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Allosteric Modulators (AMs) Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

All iGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GluN2B-NMDAR Allosteric modulator 1 Related Classifications

HY-181127 Related Classifications