GluN2B-NMDAR Allosteric modulator 1
Based on 1 Customer Validation
GluN2B-NMDAR Allosteric modulator 1 is a selective GluN2B-NMDAR positive allosteric modulator. GluN2B-NMDAR Allosteric modulator 1 can increase glutamate- and aspartate-evoked GluN2B-NMDAR-gated currents with EC50 values of 43.7 and 18 nM. GluN2B-NMDAR Allosteric modulator 1 can reverse anxiety-like behavior and social cognition deficits in mice. GluN2B-NMDAR Allosteric modulator 1 can be used for the research of neurological disease, such as anxiety.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 2419700-58-4
- Formula: C17H21N5
- Molecular Weight:295.38
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All iGluR Isoforms
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Biological Activity
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GluN2B |
GluN2B-NMDAR Allosteric modulator 1 (Compound 175) (0.001-100 μM) increases glutamate-evoked GluN1/GluN2B-NMDAR-gated currents in HEK293 cells with an EC50 of 43.7 nM (logEC50 = -7.36)[1].
GluN2B-NMDAR Allosteric modulator 1 (0.0001-1 μM) dose-dependently and selectively potentiates aspartate-evoked GluN2B-containing native NMDAR currents in primary rat hippocampal neurons with an EC50 of 18 nM[1].
GluN2B-NMDAR Allosteric modulator 1 (1 μM; 3 h) does not induce cytotoxicity in primary cortical neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
GluN2B-NMDAR Allosteric modulator 1 (1 mg/kg; i.p.; single dose) reverses anxiety-like behavior and social cognition deficits in 7-month-old Mecp2-OE mice and in a transgenic mouse line harboring an inducible expression of Disc1-N mice.[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mecp2-OE mice (7 months old); a transgenic mouse line harboring an inducible expression of Disc1-N mice (C57BL/6; 3-4 months old) [1]
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Dosage:1 mg/kg
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Administration:I.p.; single dose (30 minutes before each behavioral test)
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Result:Restored center time in the open-field test to WT levels (reversing anxiety-like behavior) and significantly improved social preference index in Mecp2-OE mice.
Increased time spent in the center of the open-field test (reversing anxiety-like behavior), increased spontaneous alternation in the Y-maze test (improving spatial working memory) and increased social preference index in the three-chamber test (reversing sociability deficit) in Disc1-N mice.
Chemical Information
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CAS No. 2419700-58-4
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Appearance Oil
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Molecular Weight 295.38
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Formula C17H21N5
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Color Light yellow to yellow
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SMILES
CC(N1C=CN=C1CNCC2=CC=C(N3C=CN=C3)C=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 4.17 mg/mL (14.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3855 mL | 16.9273 mL | 33.8547 mL | 84.6367 mL |
| 5 mM | 0.6771 mL | 3.3855 mL | 6.7709 mL | 16.9273 mL | |
| 10 mM | 0.3385 mL | 1.6927 mL | 3.3855 mL | 8.4637 mL |
GluN2B-NMDAR Allosteric modulator 1 Related Classifications
HY-181127 Related Classifications
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