GSD-11 

GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer[1].

GSD-11 (0,1, 10, 100, 1000 µM) shows potent cytotoxicity against PANC-1 cells with PC₅₀ value of 0.72 µM in nutrient-deprived medium (NDM), and IC₅₀ value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM)^[1].
GSD-11 (10 µM, 24 h) induces morphological change in PANC-1 cells^[1].
GSD-11 (3, 5 µM, 24 h) inhibits the migration of PANC-1 tumor cells^[1].
GSD-11 (1, 3, 5 µM, 24 h) shows strong colony formation inhibitory effect in PANC-1 tumor cells^[1].
GSD-11 (2.5, 5, 10 µM) inhibits the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

300.44

C₂₀H₂₈O₂

[H][C@@]12CC[C@]3([C@@]4(CC(C([C@]4(CC[C@@]3([C@]1(CCC(C2)=O)C)[H])C)=C)=O)[H])[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kohyama A, et al. Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate. Bioorg Med Chem. 2022; 54:116563.  [Content Brief]