GSK-3β inhibitor 7
GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder.
For research use only. We do not sell to patients.
- Formula: C27H23BrN4O2S
- Molecular Weight:547.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GSK-3β 5.25 μM (IC50) |
GSK-3β inhibitor 7 (Compound 6x, 5 μΜ, 3 h) shows high glucose uptake (83.5%) in musle L6 cells[1].
GSK-3β inhibitor 7 (0-30 μΜ, 30 min) inhibits GSK-3β with an IC50 value of 5.25 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
GSK-3β inhibitor 7 (intragastric administration, 1 g/kg) displays no acute toxicity at a 1 g/kg dose in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (pharmacokinetic assay)[1]
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Dosage:2 mg/kg, 20 mg/kg
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Administration:Intravenous injection (2 mg/kg), oral administration (20 mg/kg)
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Result:Pharmacokinetic profile of GSK-3β inhibitor 7 (Compound 6x).
F: oral bioavailability.Compound Route Dose (mg/kg) t1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (hr•ng/mL) AUC0-∞ (hr•ng/mL) CL (mL/hr/kg) F (%) GSK-3β inhibitor 7 Oral administration 20 5.40 1.67 507 4265 4501 4536 47.4 GSK-3β inhibitor 7 Intravenous injection 2 8.95 0.08 519 859 948.6 2138.66
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Animal Model:Male and female mice (acute assay)[1]
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Dosage:1 g/kg
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Administration:intragastric administration
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Result:Increased body weights, caused no death or obvious weight loss.
Showed no marked pathological damage in important organs (brain, heart, liver, spleen, lung, and kidney).
Chemical Information
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Molecular Weight 547.47
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Formula C27H23BrN4O2S
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SMILES
CC1=CC=C(C=C1)S(=O)(N2C=C(C3=CC(Br)=CC=C32)C4=NC(NC5=C(C=CC=C5C)C)=NC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-3β inhibitor 7 Related Classifications
HY-143261 Related Classifications
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