Globosuxanthone A
Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 917091-74-8
- Formula: C15H12O7
- Molecular Weight:304.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Globosuxanthone A shows cytotoxicities against NCI-H460, MCF-7, SF-268, PC-3, PC-3M, LNCaP, DU-145 cells (IC50=0.65-3.6 µM)[1].
Globosuxanthone A impairs cell cycle progression of NCI-H460 and PC-3M cells leading to accumulation in the G2/M and S phases [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 917091-74-8
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Molecular Weight 304.25
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Formula C15H12O7
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SMILES
O=C([C@@]1(O)C(C2=O)=C(OC3=C2C(O)=CC=C3)C=C[C@H]1O)OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Miao C, et al. Antifungal xanthones produced by the endophytic fungus Paraconionthyrium sp. YM 311593. Folia Microbiol (Praha). 2020;65(3):567-572. [Content Brief]
[2]. Wijeratne EM, et al. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg Med Chem. 2006;14(23):7917-7923. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)