A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity

  • Bioorg Med Chem. 2006 Dec 1;14(23):7917-23. doi: 10.1016/j.bmc.2006.07.048.
E M Kithsiri Wijeratne  1 ,  Thomas J Turbyville ,  Anne Fritz ,  Luke Whitesell ,  A A Leslie Gunatilaka
Affiliations
  • 1. Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA.
PMID: 16904330 DOI: 10.1016/j.bmc.2006.07.048
Abstract

Bioassay-guided fractionation of a cytotoxic EtOAc extract of the Fungal strain, Chaetomium globosum, inhabiting the rhizosphere of the Christmas cactus, Opuntia leptocaulis, of the Sonoran desert afforded a new dihydroxanthenone, globosuxanthone A (1), a new tetrahydroxanthenone, globosuxanthone B (2), two new Xanthones, globosuxanthone C (3) and D (4), 2-hydroxyvertixanthone (5), and two known Anthraquinones (6 and 7). The structures of the new compounds 1-4 were elucidated by NMR and MS techniques, and the relative stereochemistry of 1 was determined by X-ray crystallographic analysis. Of the compounds encountered, 1 was found to exhibit strong cytotoxicity against a panel of seven human solid tumor cell lines, disrupt the cell cycle leading to the accumulation of cells in either G2/M or S phase, and induce classic signs of Apoptosis.

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