2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR Monoamine Oxidase
  4. Indantadol hydrochloride

Indantadol hydrochloride (CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol hydrochloride blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol hydrochloride completely inhibits dopamine release caused by NMDA. Indantadol hydrochloride protects neurons, with an ED₅₀ of 35 μM. Indantadol hydrochloride has anticonvulsant and anti-high pain hypersensitivity activities.

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Indantadol hydrochloride

Indantadol hydrochloride Chemical Structure

CAS No. : 202914-18-9

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Based on 1 publication(s) in Google Scholar

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Indantadol hydrochloride Related Antibodies

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Description

Indantadol hydrochloride (CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol hydrochloride blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol hydrochloride completely inhibits dopamine release caused by NMDA. Indantadol hydrochloride protects neurons, with an ED₅₀ of 35 μM. Indantadol hydrochloride has anticonvulsant and anti-high pain hypersensitivity activities[1][2][3].

IC50 & Target[1][2][3]

NMDA Receptor

 

Clinical Trial
Molecular Weight

226.70

Formula

C11H15ClN2O
CAS No.
SMILES

O=C(CNC1CC2=C(C1)C=CC=C2)N.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Indantadol hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indantadol202914-18-9CHF-3381CHF3381CHF 3381iGluRMonoamine OxidaseIonotropic glutamate receptorsMAONMDA antagonistInhibitorinhibitorinhibit

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