2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR Monoamine Oxidase
  4. Indantadol

Indantadol (the free base of CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol completely inhibits dopamine release caused by NMDA. Indantadol protects neurons, with an ED₅₀ of 35 μM. Indantadol has anticonvulsant and anti-high pain hypersensitivity activities.

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Indantadol

Indantadol Chemical Structure

CAS No. : 202844-10-8

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Other Forms of Indantadol:

Indantadol Related Antibodies

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Description

Indantadol (the free base of CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol completely inhibits dopamine release caused by NMDA. Indantadol protects neurons, with an ED₅₀ of 35 μM. Indantadol has anticonvulsant and anti-high pain hypersensitivity activities[1][2][3].

IC50 & Target[1][2][3]

NMDA Receptor

 

Molecular Weight

190.24

Formula

C11H14N2O
CAS No.
SMILES

O=C(N)CNC1CC2=C(C=CC=C2)C1
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Indantadol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indantadol202844-10-8CHF-3381CHF3381CHF 3381iGluRMonoamine OxidaseIonotropic glutamate receptorsMAOInhibitorinhibitorinhibit

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