Aβ42-IN-1
Aβ42-IN-1, compound 1v, is a novel, potent and orally active?γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
For research use only. We do not sell to patients.
- CAS No.: 2582757-69-3
- Formula: C29H27ClN4O2
- Molecular Weight:499.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.091 µM (γ-secretase modulator)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8- week-old male ddY mice
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Dosage:30 mg/kg
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Administration:Orally adminstation; 30 mg/kg
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Result:Reduced Aβ42 levels in the brain and plasma, by 36% and 66%, respectively.
Chemical Information
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CAS No. 2582757-69-3
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Molecular Weight 499.00
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Formula C29H27ClN4O2
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SMILES
O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aβ42-IN-1 Related Classifications
HY-130609 Related Classifications
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