EIF5A - eukaryotic translation initiation factor 5A Gene

Also Known as FABAS; EIF-5A; EIF5A1; eIF-4D; eIF5AI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1984

About EIF5A

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,306,999-7,312,463 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 207 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 53.8), appendix (RPKM 49.4) and 25 other tissues.

Summary

Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]

EIF5A Products (6)

mRNA Protein Name
NM_001143760.1 NP_001137232.1 eukaryotic translation initiation factor 5A-1 isoform A
NM_001143761.1 NP_001137233.1 eukaryotic translation initiation factor 5A-1 isoform B
NM_001143762.2 NP_001137234.1 eukaryotic translation initiation factor 5A-1 isoform B
NM_001370420.1 NP_001357349.1 eukaryotic translation initiation factor 5A-1 isoform B
NM_001370421.1 NP_001357350.1 eukaryotic translation initiation factor 5A-1 isoform B
NM_001970.5 NP_001961.1 eukaryotic translation initiation factor 5A-1 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
15303967 GOA
enables U6 snRNA binding IDA
IDA: Inferred from direct assay
9285100 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9442029 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
8596953 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: Inferred from direct assay
15371445 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15371445 GOA
involved in translational elongation IMP
IMP: Inferred from mutant phenotype
29712776 GOA
involved in tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
17187778 GOA
Cellular Component GO Annotation Evidence References Source
located in annulate lamellae IDA
IDA: Inferred from direct assay
12210765 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12210765 GOA
part of nuclear pore IDA
IDA: Inferred from direct assay
10381392 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12210765 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5A Protein Structure

eIF-5a

eIF-5a: Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold (83 - 150)

  • 0
  • 100
  • 154 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 5A-1

  • eukaryotic initiation factor 5A

EIF5A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF5A P63241 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
EIF5A P63241 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
EIF5A P63241 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
EIF5A P63241 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
EIF5A P63241 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
EIF5A P63241 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
EIF5A P63241 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
EIF5A P63241 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
EIF5A P63241 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
EIF5A P63241 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra
EIF5A P63241 LBX1 Homo sapiens P52954
Y2H Array
32296183
Intra
EIF5A P63241 LBX1 Homo sapiens P52954
Y2H Prey Pooling
32296183
Intra
EIF5A P63241 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
EIF5A P63241 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
EIF5A P63241 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
EIF5A P63241 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
EIF5A P63241 DHPS Homo sapiens P49366
Validated Y2H
25416956
Intra
EIF5A P63241 CRX Homo sapiens O43186
Validated Y2H
25416956
Intra
EIF5A P63241 CRX Homo sapiens O43186
Y2H Prey Pooling
25416956
Intra
EIF5A P63241 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
EIF5A P63241 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
EIF5A P63241 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
EIF5A P63241 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF5A Proteins

Cat. No. Product Name Accession Purity
HY-P78232 EIF5A Protein, Human (His) NP_001961 (M1-K154) ≥ 95%, as determined by reducing SDS-PAGE.

EIF5A Antibodies

Cat. No. Product Name Application Reactivity
HY-P80653 eIF5A Antibody (YA461) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Faundes-Banka Syndrome

  • FABAS
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Syndromic X-Linked Intellectual Disability Snyder Type

  • Snyder-Robinson Syndrome

  • Mental Retardation, X-Linked, Snyder-Robinson Type

  • Spermine Synthase Deficiency

  • Srs

  • Snyder-Robinson Mental Retardation Syndrome

  • X-Linked Intellectual Disability Snyder-Robinson Type

  • Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

  • Snyder-Robinson X-Linked Mental Retardation Syndrome
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2397 9''-Methyl salvianolate B 99.54% Unkown
HY-111522 RK-9123016 Inhibitor 99.65% Unkown
HY-106801 Girolline / Unkown
HY-RS04286 EIF5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W141446 VT00065 Inhibitor ≥98.0% Unkown
HY-121722 Deoxyhypusine / Unkown
HY-122039 Hypusine dihydrochloride / Unkown
HY-RS04285 EIF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04287 EIF5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126171 Hypusine / Unkown
HY-RS19060 Eif5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19678 Eif5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25550 Eif5a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26171 Eif5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EIF5A MGD MGI:106248
Rattus norvegicus EIF5A RGD RGD:1308029
Others EIF5A NCBI