PDCD4 - programmed cell death 4 Gene

Also Known as H731

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27250

About PDCD4

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,871,928-110,900,006 (from NCBI)

This gene has 11 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in colon (RPKM 80.4), thyroid (RPKM 70.8) and 25 other tissues.

Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

PDCD4 Products (3)

mRNA Protein Name
NM_001199492.2 NP_001186421.1 programmed cell death protein 4 isoform 3
NM_014456.5 NP_055271.2 programmed cell death protein 4 isoform 1
NM_145341.4 NP_663314.1 programmed cell death protein 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12054647 GOA
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
18548003 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16357133 GOA
involved in negative regulation of myofibroblast differentiation IMP
IMP: Inferred from mutant phenotype
20533548 GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
18548003 GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
28522568 GOA
involved in positive regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24732886 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19946272 GOA
involved in positive regulation of vascular associated smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
28522568 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
16357133 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12054647 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
16357133 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD4 Protein Structure

MA3

MA3: MA3 domain (164 - 274)

MA3

MA3: MA3 domain (329 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

programmed cell death protein 4

  • neoplastic transformation inhibitor protein

PDCD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDCD4 Q53EL6 APOE Homo sapiens P02649
Anti Bait CoIP
21163940
Intra
PDCD4 Q53EL6 EIF4A3 Homo sapiens P38919
Y2H Prey Pooling
32296183
Intra
PDCD4 Q53EL6 EIF4A3 Homo sapiens P38919
Validated Y2H
25416956
Intra
PDCD4 Q53EL6 EIF4A3 Homo sapiens P38919
Y2H Array
25416956
Intra
PDCD4 Q53EL6 EIF4A3 Homo sapiens P38919
Y2H Array
32296183
Intra
PDCD4 Q53EL6 RPS13 Homo sapiens P62277
Y2H
12054647
Intra
PDCD4 Q53EL6 EIF4A1 Homo sapiens P60842
Anti Bait CoIP
24413684
Intra
PDCD4 Q53EL6 EIF4A2 Homo sapiens Q14240
Anti Bait CoIP
17353931
Intra
PDCD4 Q53EL6 EIF4A2 Homo sapiens Q14240
Validated Y2H
25416956
Intra
PDCD4 Q53EL6 EIF4A2 Homo sapiens Q14240
Y2H Array
25416956
Intra
PDCD4 Q53EL6 RELA Homo sapiens Q04206
Anti Tag CoIP
24413684
Intra
PDCD4 Q53EL6 RELA Homo sapiens Q04206
Anti Bait CoIP
24413684
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD4 Proteins

Cat. No. Product Name Accession Purity
HY-P71191 PDCD4 Protein, Human (His) Q53EL6 (K212-P357) ≥ 95%, as determined by reducing SDS-PAGE.

PDCD4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80269 PDCD4 Antibody (YA240) WB, ICC/IF, IHC-P, FC Human, Mouse

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Ciliary Dyskinesia, Primary, 30

  • Primary Ciliary Dyskinesia 30

  • CILD30

  • Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus

  • Primary Ciliary Dyskinesia 30 Without Situs Inversus

  • Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus

  • Dyskinesia, Ciliary, Primary, Type 30
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145232 PhosTAC7 99.23% Unkown
HY-153383 PDCD4-IN-1 Inhibitor 99.41% Unkown
HY-148509 PhosTAC5 98.02% Unkown
HY-148508 PhosTAC3 Inhibitor 99.97% Unkown
HY-RS10192 PDCD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17345 Pdcd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23799 Pdcd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDCD4 VGNC VGNC:75794
Rattus norvegicus PDCD4 RGD RGD:620816
Mus musculus PDCD4 MGD MGI:107490
Felis catus PDCD4 VGNC VGNC:68744
Bos taurus PDCD4 VGNC VGNC:32661
Canis familiaris PDCD4 VGNC VGNC:44338
Others PDCD4 NCBI