2. Gene
  3. EIF4A1 - eukaryotic translation initiation factor 4A1 Gene

EIF4A1 - eukaryotic translation initiation factor 4A1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I

Gene ID: 1973 | Gene type: protein coding

About EIF4A1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,572,825-7,579,006 (from NCBI)

This gene has 36 transcripts (splice variants), 131 orthologues and 38 paralogues. Ubiquitous expression in appendix (RPKM 182.3), bone marrow (RPKM 177.5) and 25 other tissues.

Summary

Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EIF4A1 Products(2)

mRNA Protein Name
NM_001204510.2 NP_001191439.1 eukaryotic initiation factor 4A-I isoform 2
NM_001416.4 NP_001407.1 eukaryotic initiation factor 4A-I isoform 1

EIF4A1 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (57 - 222)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (292 - 367)

  • 0
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  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

eukaryotic initiation factor 4A-I

ATP-dependent RNA helicase eIF4A-1

Related Diseases

Diseases Alias
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108666 ATPγS tetralithium salt Chemical ≥98.0% Unkown
HY-19560 SBI-0640756 Inhibitor 99.76% Unkown
HY-129768 CMLD012072 Inhibitor / Unkown
HY-129769 CMLD012073 Inhibitor / Unkown
HY-145240 eIF4E-IN-1 Inhibitor / Unkown
HY-RS04270 EIF4A1 Human Pre-designed siRNA Set A / Unkown
HY-RS04277 EIF4EBP1 Human Pre-designed siRNA Set A / Unkown
HY-RS04280 EIF4ENIF1 Human Pre-designed siRNA Set A / Unkown
HY-RS04281 EIF4G1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EIF4A1 RGD RGD:735141
Felis catus EIF4A1 VGNC VGNC:98947
Mus musculus EIF4A1 MGD MGI:95303
Bos taurus EIF4A1 VGNC VGNC:28404
Macaca mulatta EIF4A1 VGNC VGNC:99145
Others EIF4A1 NCBI