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Art. -Nr.: HY-176842

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eIF4A-IN-1

eIF4A-IN-1 (Compound 79) is an eIF4A inhibitor that inhibits protein translation. eIF4A-IN-1 canb be used in gastric cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3083974-55-1
Formel: C₃₁H₃₃N₃O₅
Molecular Weight:527.61

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

eIF4A-IN-1 Chemical Structure

CAS. Nr.: 3083974-55-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

eIF4A-IN-1 (Compound 79) is an eIF4A inhibitor that inhibits protein translation. eIF4A-IN-1 canb be used in gastric cancer research^[1].

IC₅₀ & Target^[1]

eIF4

In Vitro

Aberrant messenger RNA (mRNA) translation is a common feature of malignant tumors, characterized by the upregulation of oncoproteins, growth factors, and signal transduction proteins associated with proliferation, survival, and metastasis. The expression of oncogenic driver genes is tightly regulated at the translational level and is controlled by the eukaryotic translation initiation factor 4F (eIF4F) complex. Hyperactivation of eIF4A correlates with poor prognosis in multiple related diseases, including lymphoma, lung cancer, colorectal cancer, liver cancer, breast cancer, and ovarian cancer. The eIF4A family consists of three members: eIF4A1, eIF4A2, and eIF4A3, all of which belong to the DEAD-box helicase family. Proteins of this family all possess 9 conserved motifs, which are involved in RNA binding or ATP hydrolysis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3083974-55-1
Molecular Weight 527.61
Formel C₃₁H₃₃N₃O₅
SMILES

O[C@]12[C@](OC3=CC(C4=NC=CO4)=CC(OC)=C32)(C5=CC=C(C=C5)OC)[C@H](C6=CC(N)=CC=C6)C[C@@H]1CN(C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bing Li, et al. Conjugate of protein translation inhibitor and use thereof. WO2025153015A2.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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