TNFSF15 - TNF superfamily member 15 Gene

Also Known as TL1; TL1A; VEGI; TNLG1B; VEGI192A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9966

About TNFSF15

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,784,635-114,806,039 (from NCBI)

This gene has 2 transcripts (splice variants), 122 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in duodenum (RPKM 4.3), urinary bladder (RPKM 3.6) and 17 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce Apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

TNFSF15 Products (2)

mRNA	Protein	Name
NM_001204344.1	NP_001191273.1	tumor necrosis factor ligand superfamily member 15 isoform VEGI-192
NM_005118.4	NP_005109.2	tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21300286	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within activation of NF-kappaB-inducing kinase activity	IDA IDA: Inferred from direct assay	11911831	GOA
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	11911831	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11911831	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFSF15 Protein Structure

TNF

0
100
200
251 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor ligand superfamily member 15	TNF ligand-related molecule 1

TNFSF15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFSF15	O95150	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	TNFSF15	O95150	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	TNFSF15	O95150	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	TNFSF15	O95150	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	TNFSF15	O95150	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	TNFSF15	O95150	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFSF15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71913	TL1A/TNFSF15 Protein, Human	O95150-1 (L72-L251)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71981	TL1A/TNFSF15 Protein, Human (O95150-2, HEK293, His)	O95150-2 (M1-L192)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78447	TL1A/TNFSF15 Trimer Protein, Human (HEK293, His-Flag)	O95150-1 (D91-L251)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P700153AF	Animal-Free TL1A/TNFSF15 Protein, Human (His)	O95150-1 (Q58-L251)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701048	TL1A/TNFSF15 Protein, Human (180a.a, HEK293, His)	O95150-1 (L72-L251)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

TNFSF15 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89406	TNFSF15 Antibody	WB, IHC-P, mIHC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Diverticulitis
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Inflammatory Bowel Disease 15	IBD15
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Inflammatory Bowel Disease 5	IBD5
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 19 IBD19 Bowel Disease, Inflammatory, Type 19
Intestinal Tuberculosis	Tuberculosis Of Intestine Tuberculosis Of Intestines
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Ileitis	Crohn'S Ileitis
Epilepsy, Familial Temporal Lobe, 2	Familial Temporal Lobe Epilepsy 2 Temporal Epilepsy, Familial ETL2 Ftle Epilepsy, Familial Temporal Lobe Familial Temporal Lobe Epilepsy
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990007	Tulisokibart	Inhibitor	99.00%	Phase 3
HY-P990006	Duvakitug	Inhibitor	99.76%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14826	TNFSF15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17391	Tnfsf15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23846	Tnfsf15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990151	Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)	Inhibitor	95.00%	Unkown
HY-P991440	AMG-966	Inhibitor	96.19%	Unkown
HY-P992444	PR200	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF15	VGNC	VGNC:36174
Canis familiaris	TNFSF15	VGNC	VGNC:47671
Rattus norvegicus	TNFSF15	RGD	RGD:628735
Mus musculus	TNFSF15	MGD	MGI:2180140
Macaca mulatta	TNFSF15	VGNC	VGNC:78596
Felis catus	TNFSF15	VGNC	VGNC:66415
Others	TNFSF15	NCBI