Rilmenidine phosphate
Based on 1 Customer Validation
Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 85409-38-7
- Formula: C10H19N2O5P
- Molecular Weight:278.24
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors[1].
Rilmenidine phosphate (25-100 μM; 24 hours) inhibits K562 cell proliferation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 cells
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Concentration:25, 50, 100 μM
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Incubation Time:24 hours
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Result:Dose-dependently inhibited K562 colony formation.
Rilmenidine phosphate decreases levels of mutant huntingtin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 85409-38-7
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Appearance Solid
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Molecular Weight 278.24
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Formula C10H19N2O5P
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Color White to off-white
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SMILES
O=P(O)(O)O.C1(NC(C2CC2)C3CC3)=NCCO1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 83.33 mg/mL (299.49 mM; Need ultrasonic)
DMSO : 5 mg/mL (17.97 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [Content Brief]
[2]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180. [Content Brief]
[3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.5940 mL | 17.9701 mL | 35.9402 mL | 89.8505 mL |
| 5 mM | 0.7188 mL | 3.5940 mL | 7.1880 mL | 17.9701 mL | |
| 10 mM | 0.3594 mL | 1.7970 mL | 3.5940 mL | 8.9850 mL | |
| 15 mM | 0.2396 mL | 1.1980 mL | 2.3960 mL | 5.9900 mL | |
| H2O | 20 mM | 0.1797 mL | 0.8985 mL | 1.7970 mL | 4.4925 mL |
| 25 mM | 0.1438 mL | 0.7188 mL | 1.4376 mL | 3.5940 mL | |
| 30 mM | 0.1198 mL | 0.5990 mL | 1.1980 mL | 2.9950 mL | |
| 40 mM | 0.0899 mL | 0.4493 mL | 0.8985 mL | 2.2463 mL | |
| 50 mM | 0.0719 mL | 0.3594 mL | 0.7188 mL | 1.7970 mL | |
| 60 mM | 0.0599 mL | 0.2995 mL | 0.5990 mL | 1.4975 mL | |
| 80 mM | 0.0449 mL | 0.2246 mL | 0.4493 mL | 1.1231 mL | |
| 100 mM | 0.0359 mL | 0.1797 mL | 0.3594 mL | 0.8985 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Rilmenidine phosphate Related Classifications
HY-100490B Related Classifications
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