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Cat. No.: HY-182409

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TSI-13-48

TSI-13-48 (HY-182409) is a TLR inhibitor with IC₅₀ values of 3.02, 22.3, 26.5, and 26.6 μM against TLR9, TLR7, TLR2, and TLR4, respectively. TSI-13-48 can be used in research related to systemic lupus erythematosus, polymicrobial sepsis, and cerebral malaria.

For research use only. We do not sell to patients.

CAS No.: 2254006-84-1
Formula: C₂₉H₃₀N₄O₄
Molecular Weight:498.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TSI-13-48 Chemical Structure

CAS No.: 2254006-84-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 2254006-84-1
Molecular Weight 498.57
Formula C₂₉H₃₀N₄O₄
SMILES

COC1=CC=C(C=C1)C2=CC(C3=CC=C(OCCN4CCCCC4)C=C3)=NN2C(C=C5)=CC=C5[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pollock JA, et al. Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure-Activity Relationships Governing Pan- and Selective Signaling Inhibitors. ChemMedChem. 2018;13(20):2208-2216. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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