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Liothyronine

(Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)
40 Cited Publications
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Based on 40 publication(s) in Google Scholar

Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with Kis of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR.

For research use only. We do not sell to patients.

  • Purity: 99.82%
  • CAS No.: 6893-02-3
  • Formula: C15H12I3NO4
  • Molecular Weight:650.97
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • Liothyronine Chemical Structure
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
  • Liothyronine Chemical Structure
    Liothyronine Chemical Structure
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
  • Experimental Validation Results for Liothyronine
CAS No.: 6893-02-3
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  • Liothyronine Chemical Structure
    Liothyronine Chemical Structure
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    Liothyronine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 9:e08571. [Abstract]

    Customer Validation
     PGC1α mRNA levels in TRβ‐overexpressing ccRCC cell lines versus controls following Triiodothyronine (T3) treatment (100 nM for 48 h).

  • 1/16

    Liothyronine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 9:e08571. [Abstract]

    Customer Validation
     CCK8 assay showing proliferation of TRβ-overexpressing cells treated with T3 (100 nM for 48 h).

  • 1/16

    Liothyronine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 9:e08571. [Abstract]

    Customer Validation
     Transwell assay results comparing the migration of TRβ-overexpressing cells with control cells in the presence of T3 (100 nM for 48 h).

  • 1/16

    Liothyronine purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Nov 7;35(11):1915-1930.e8. [Abstract]

    Customer Validation
     C3H10T1/2 preadipocytes were treated with differentiation medium supplemented with 0.5 mM 3-isobutyl-1-methylxanthine, 1 μM Dexamethasone, 850 nM Insulin, 1 nM Triiodothyronine, 125 nm Indomethacin and 1 μM Rosiglitazone for 2 days and subsequently cultured in maintaining medium supplemented with 1 nM Triiodothyronine, 850 nM Insulin, and 1 μM Rosiglitazone for another 2 days. Differentiated adipocytes at day 4 were cultured in complete medium until used for experiments. Representative immunoblots of PGC-1α and UCP1 in beige adipocytes treated as indicated.

  • 1/16

    Liothyronine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jun 2;14(1):3208. [Abstract]

    Customer Validation
     C3H10T1/2 preadipocytes were cultured in DMEM supplemented with 10% FBS, 1% P/S. For adipogenic differentiation, confluent C3H10T1/2 preadipocytes were incubated with complete medium supplemented with 0.5 mM 3-isobutyl-1-methylxanthine, 1 μM Dexamethasone, 850 nM Insulin, 1 nm Triiodothyronine, 125 nm Indomethacin and 1 μM Rosiglitazone for 2 days. Then, cells were changed to the complete medium supplemented with 1 nM T3, 850 nM Insulin, and 1 μM Rosiglitazone for another 2 days. Differentiated adipocytes at day 4 were maintained in complete medium until used for experiments. Representative immunoblots of NRP1 and EPHA7 in differentiated brown adipocytes transfected with si-Rbm3 or si-NC.

  • Liothyronine