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Cat. No.: HY-N10577

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Chlorfortunone A

Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity.

For research use only. We do not sell to patients.

Formula: C₃₁H₃₈O₅
Molecular Weight:490.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Chlorfortunone A Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity^[1].

All TGF-beta/Smad Isoforms :

Smad1
Smad3

In Vitro

Chlorfortunone A (compound 1) (10-40 μM; 4 h) downregulates TGF-β-induced Smad2 phosphorylation (A) and the expression of vimentin (B) in MDA-MB-231 cells^[1].
Chlorfortunone A (25 μM; 48 h) significantly downregulated the expression of vimentin, a Smad-regulated EMT-marker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

10, 20, 40 μM
Incubation Time:

4 hours; accompanied with 10 ng/mL TGF-β1 for 30 min
Result:

Significantly downregulated the TGF-β-induced p-Smad2 expression in a concentration-dependent manner without any impact on the expression of Smad2/3 protein.

Immunofluorescence^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

25 μM
Incubation Time:

48 hours
Result:

Significantly downregulated the expression of vimentin.

Chemical Information

Molecular Weight 490.63
Formula C₃₁H₃₈O₅
SMILES

C[C@@]1([C@@H]2C[C@@H]2C(CC3)=C1[C@]([C@]3(C=C4)C=C[C@@]4([C@@H](C(C)C)C5)[C@@H](C5=O)C)([H])/C6=C(C)/C(OC)=O)[C@@H](O)C6=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu xujia, et al. Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei. ACS Omega 2022.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Chlorfortunone A

All TGF-beta/Smad Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Chlorfortunone A Related Classifications

HY-N10577 Related Classifications