TLR1 - toll like receptor 1 Gene

Also Known as TIL; CD281; rsc786; TIL. LPRS5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7096

About TLR1

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:38,787,569-38,805,644 (from NCBI)

This gene has 10 transcripts (splice variants), 73 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in appendix (RPKM 7.0), spleen (RPKM 4.9) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than Other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

TLR1 Products (11)

mRNA	Protein	Name
XM_011513742.4	XP_011512044.1	toll-like receptor 1 isoform X1
XR_007057954.1
XM_011513745.4	XP_011512047.1	toll-like receptor 1 isoform X1
XM_005262662.6	XP_005262719.1	toll-like receptor 1 isoform X1
XR_007057953.1
XM_017008571.3	XP_016864060.1	toll-like receptor 1 isoform X1
XR_925165.3
NM_003263.4	NP_003254.2	toll-like receptor 1 precursor
XM_024454196.2	XP_024309964.1	toll-like receptor 1 isoform X1
XM_017008572.3	XP_016864061.1	toll-like receptor 1 isoform X1
XR_925163.3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Toll-like receptor 2 binding	IPI IPI: Inferred from physical interaction	16880211	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23155421	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15728506	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to triacyl bacterial lipopeptide	IDA IDA: Inferred from direct assay	19931471	GOA
involved in cellular response to triacyl bacterial lipopeptide	IDA IDA: Inferred from direct assay	16880211	GOA
acts upstream of or within detection of triacyl bacterial lipopeptide	IDA IDA: Inferred from direct assay	19931471	GOA
involved in positive regulation of interleukin-8 production	IGI IGI: Inferred from genetic interaction	22198949	GOA
involved in positive regulation of toll-like receptor 2 signaling pathway	IGI IGI: Inferred from genetic interaction	22198949	GOA
involved in toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	16893894	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16880211	GOA
part of Toll-like receptor 1-Toll-like receptor 2 protein complex	IDA IDA: Inferred from direct assay	17889651	GOA
part of Toll-like receptor 1-Toll-like receptor 2 protein complex	IPI IPI: Inferred from physical interaction	17889651	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	16880211	GOA
part of receptor complex	IPI IPI: Inferred from physical interaction	23155421	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR1 Protein Structure

LRR_8

TIR

0
200
400
600
786 a.a.

Protein Preferred Names	Protein Names
toll-like receptor 1	toll/interleukin-1 receptor-like protein

TLR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TLR1	Q15399	TLR6	Homo sapiens	Q9Y2C9	ToxCat	23155421
Intra	TLR1	Q15399	TLR6	Homo sapiens	Q9Y2C9	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	TLR10	Homo sapiens	Q9BXR5	ToxCat	23155421
Intra	TLR1	Q15399	TLR10	Homo sapiens	Q9BXR5	Anti Tag CoIP	15728506
Intra	TLR1	Q15399	TLR2	Homo sapiens	O60603	FRET	23155421
Intra	TLR1	Q15399	TMEM214	Homo sapiens	Q6NUQ4	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	TLR2	Homo sapiens	O60603	ToxCat	23155421
Intra	TLR1	Q15399	TLR1	Homo sapiens	Q15399	Fluorescence	23155421
Intra	TLR1	Q15399	TLR1	Homo sapiens	Q15399	ToxCat	23155421
Intra	TLR1	Q15399	COLEC12	Homo sapiens	Q5KU26	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	DERA	Homo sapiens	Q9Y315	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	TMX1	Homo sapiens	Q9H3N1	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	LRP6	Homo sapiens	O75581	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	MUCL1	Homo sapiens	Q96DR8	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	STK11IP	Homo sapiens	Q8N1F8	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	CNPY3	Homo sapiens	Q9BT09	Anti Tag CoIP	33961781
Intra	TLR1	Q15399	ALDH16A1	Homo sapiens	Q8IZ83	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

TLR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84586	CD281 Antibody (YA4283)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84586A	CD281 Antibody (YA4283)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Filariasis	Disease Due To Superfamily Filarioidea Bancroftian Filarial Fever Mumu Wanganga Bancroftian Filariasis Wuchereriosis Brugiosis Malayan Filariasis
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Bacteriuria
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Primary Bacterial Infectious Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Lepromatous Leprosy	Leprosy, Lepromatous Type L Leprosy Leprosy Lepromatous
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Pharyngitis	Acute Pharyngitis Chronic Pharyngitis Acute Sore Throat Chronic Sore Throat Persistent Sore Throat Pharyngeal Diseases Chronic Pharyn/Nasopharyngitis Chronic Pharyngitis And Nasopharyngitis Inflamed Throat Pharyngeal Disease Pharyngeal Disorder Pharyngitis - Acute Sore Throat - Chronic Acute Pharyngitis Nos Acute Sore Throat Nos Acute Throat Inflammation Infective Pharyngitis Infection Of Pharynx Acute Infective Pharyngitis Acute Infective Pharyngitis Nos Acute Pharyngeal Inflammation Inflammation Of The Throat Throat Inflammation Throat Infection Putrid Pharyngitis Pharyngeal Inflammation Pharyngitis Nos Chronic Throat Pain Throat Catarrh
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Pelvic Inflammatory Disease	Pid
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Tonsillitis	Chronic Tonsillitis Throat Infection - Tonsillitis
Leptospirosis	Fort Bragg Fever Weil Disease Leptospirosis Icterohaemorrhagica Nanukayami Fever Canicola Fever Hemorrhagic Jaundice Mud Fever Stuttgart Disease Swamp Fever Rat Catcher'S Yellows Spirochetal Jaundice Weil'S Disease Cane-Cutter Fever Icterohemorrhagic Fever Rice-Field Fever Swineherd'S Disease Weil Syndrome Nanukayami Canine Leptospirosis Equine Infectious Anemia Leptospirosis Canicola Fever Due To Leptospira Autumnalis Gikiyami Leptospira Interrogans Autumnalis Infection Leptospira Interrogans Canicola Infection Leptospira Interrogans Hebdomadis Infection Leptospira Interrogans Pomona Infection Nanukayami Disease Pretibial Fever Seven-Day Fever Eia - [Equine Infectious Anaemia] Leptospira Interrogans Infection
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Leprosy 5	Leprosy, Susceptibility To, 5 Leprosy, Protection Against LPRS5 Leprosy, Type 5
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Q Fever	Infection Due To Coxiella Burnetii Quadrilateral Fever Query Fever Nine Mile Fever Coxiella Burnetii Fever Q Fever Pneumonia Coxiellosis Pneumonia In Q Fever Australian Q Fever Balkan Grippe
Tuberculoid Leprosy	Smooth Leprosy Type T Leprosy Leprosy Tuberculoid Leprosy, Tuberculoid
Gastrointestinal Tularemia	Enteric Tularemia Intestinal Tularaemia
Neurosyphilis	Syphilis Of Central Nervous System Late Syphilis Of Central Nervous System Nos Late Syphilis Of The Central Nervous System Gumma Of Central Nervous System Neurosyphilis Gumma Neurosyphilitic Gumma Syphilis Of Central Nervous System Nos Syphilitic Gumma Of Central Nervous System Tertiary Central Nervous System Syphilis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1180A	Pam3CSK4 TFA	Agonist	99.89%	Unkown
HY-108471	CU-CPT22	Inhibitor	≥99.0%	Unkown
HY-123942	Diprovocim	Agonist	98.82%	Unkown
HY-110353	CU-T12-9	Agonist	99.96%	Unkown
HY-150501	Diprovocim-X	Agonist	98.64%	Unkown
HY-P1180	Pam3CSK4	Agonist	/	Unkown
HY-183301	TLR2/1 agonist-1	Agonist	/	Unkown
HY-P1405	Pam3CSK4-Biotin	Agonist	/	Unkown
HY-175293	SMU-C68	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TLR1	VGNC	VGNC:78372
Canis familiaris	TLR1	VGNC	VGNC:53247
Rattus norvegicus	TLR1	RGD	RGD:1309975
Mus musculus	TLR1	MGD	MGI:1341295
Felis catus	TLR1	VGNC	VGNC:82315
Others	TLR1	NCBI