DERA - deoxyribose-phosphate aldolase Gene

Also Known as DEOC; CGI-26

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51071

About DERA

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,911,332-16,037,381 (from NCBI)

This gene has 10 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in small intestine (RPKM 26.2), kidney (RPKM 24.6) and 25 other tissues.

Summary

Enables deoxyribose-phosphate aldolase activity. Involved in deoxyribonucleoside catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DERA Products (2)

mRNA Protein Name
NM_001300779.2 NP_001287708.1 deoxyribose-phosphate aldolase isoform 2
NM_015954.4 NP_057038.2 deoxyribose-phosphate aldolase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables deoxyribose-phosphate aldolase activity IDA
IDA: Inferred from direct assay
9226884 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in deoxyribonucleoside catabolic process IDA
IDA: Inferred from direct assay
9226884 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DERA Protein Structure

DeoC

DeoC: DeoC/LacD family aldolase (52 - 292)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
Protein Preferred Names Protein Names

deoxyribose-phosphate aldolase

  • 2-deoxy-D-ribose 5-phosphate aldolase

DERA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DERA Q9Y315 ALDH16A1 Homo sapiens Q8IZ83
Y2H Array
32296183
Intra
DERA Q9Y315 ALDH16A1 Homo sapiens Q8IZ83
Anti Tag CoIP
33961781
Intra
DERA Q9Y315 ALDH16A1 Homo sapiens Q8IZ83
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mast Syndrome

  • SPG21

  • Spastic Paraplegia 21, Autosomal Recessive

  • Autosomal Recessive Spastic Paraplegia Type 21

  • Autosomal Recessive Spastic Paraplegia 21

  • Hereditary Spastic Paraplegia 21
Balanitis Xerotica Obliterans

  • Penile Lichen Sclerosus

  • Penile Leukoplakia
Streptococcal Meningitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147061 2-Deoxyribose 5-phosphate disodium 99% Unkown
HY-RS03698 DERA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21322 Dera Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27841 Dera Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DERA VGNC VGNC:61447
Mus musculus DERA MGD MGI:1913762
Bos taurus DERA VGNC VGNC:28009
Macaca mulatta DERA VGNC VGNC:71696
Canis familiaris DERA VGNC VGNC:39901
Rattus norvegicus DERA RGD RGD:1589836
Others DERA NCBI