TLR2/1 agonist-1
TLR2/1 agonist-1 is a selective agonist of the TLR2/1 heterodimer. TLR2/1 agonist-1 acts as a hematopoietic recovery inducer to accelerate the recovery of peripheral blood cells. TLR2/1 agonist-1 serves as a G-CSF production inducer to increase serum G-CSF levels. TLR2/1 agonist-1 exhibits radioprotective effects in mice exposed to radiation. TLR2/1 agonist-1 can be used in studies related to acute radiation syndrome.
For research use only. We do not sell to patients.
- Formula: C17H11FN4O3
- Molecular Weight:338.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR2 |
TLR1 |
TLR2/1 agonist-1 (10 μM) significantly activates TLR2/1 signaling in transiently co-transfected HEK 293 T cells, with an RLU fold value of 1.674[1].
TLR2/1 agonist-1 (0.001-10 μM) dose-dependently upregulates TLR2 and TLR1 expression, but does not affect TLR6 expression, in PMA-differentiated THP-1 cells[1].
TLR2/1 agonist-1 (10 μM) specifically promotes heterodimerization of the TLR2/1 complex, rather than TLR2/6, in PMA-differentiated THP-1 cells[1].
TLR2/1 agonist-1 (10 μM) binds directly to the TLR2/1 heterodimer, enhancing the thermal stability of both TLR2 and TLR1 proteins in PMA-differentiated THP-1 cells[1].
TLR2/1 agonist-1 (0.01-10 μM) dose-dependently stimulates IL-6 secretion in PMA-differentiated THP-1 cells, confirming activation of downstream TLR2/1 signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TLR2/1 agonist-1 (60 mg/kg; intraperitoneal injection; 24 h and 30 min before irradiation) promotes the recovery of peripheral blood WBC, RBC, HGB and PLT counts in male C57BL/6 J mice exposed to 6.5 Gy 60Co γ-rays, and the levels at multiple time points after irradiation are significantly higher than those in the control group[1].
TLR2/1 agonist-1 (80 mg/kg; intraperitoneal injection; 24 h and 30 min before irradiation) significantly increases the peripheral blood G-CSF level in irradiated male C57BL/6 J mice, which is approximately 14 times that of non-irradiated control mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J (male, exposed to 8.5 Gy of 60Co γ-rays)[1]
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Dosage:80 mg/kg; 60 mg/kg; 30 mg/kg
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Administration:i.p.; 24 h and 30 min before radiation
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Result:Achieved a 100% 30-day survival rate at 80 mg/kg and 60 mg/kg.
Achieved a 20% 30-day survival rate at 30 mg/kg.
Showed the fastest body weight recovery among drug treatment groups after an initial post-radiation decrease at 80 mg/kg.
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Animal Model:C57BL/6 J (male, exposed to 6.5 Gy of 60Co γ-rays)[1]
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Dosage:60 mg/kg
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Administration:i.p.; 24 h and 30 min before radiation
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Result:Exhibited significantly higher WBC count than the control group on days 18 and 22 post-irradiation, with faster recovery after the nadir on day 4.
Showed significantly higher RBC count than the control group on days 14 and 18 post-irradiation, returning to normal levels by day 18 (vs. day 22 for the control group).
Had significantly higher HGB levels than the control group on days 14 and 18 post-irradiation, with faster recovery after the nadir on day 14.
Demonstrated significantly higher PLT count than the control group on days 14, 18, and 22 post-irradiation, with recovery after the nadir on day 10.
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Animal Model:C57BL/6 J (male, exposed to 60Co γ-rays)[1]
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Dosage:80 mg/kg
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Administration:i.p.; 24 h and 30 min before radiation
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Result:Caused a sharp increase in peripheral blood G-CSF levels, which were approximately 14-fold higher than levels in unirradiated control mice and significantly elevated compared to irradiated control mice.
Chemical Information
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Molecular Weight 338.29
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Formula C17H11FN4O3
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SMILES
O=[N+](C1=CC(N2C=C(N=N2)C3=CC4=C(OC3)C=CC(F)=C4)=CC=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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