TLR10 - toll like receptor 10 Gene

Also Known as CD290

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81793

About TLR10

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:38,772,238-38,782,990 (from NCBI)

This gene has 8 transcripts (splice variants), 56 orthologues and 22 paralogues. Biased expression in lymph node (RPKM 20.4), spleen (RPKM 11.7) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

TLR10 Products (5)

mRNA Protein Name
NM_001017388.3 NP_001017388.1 toll-like receptor 10 isoform a
NM_001195106.2 NP_001182035.1 toll-like receptor 10 isoform a
NM_001195107.2 NP_001182036.1 toll-like receptor 10 isoform a
NM_001195108.2 NP_001182037.1 toll-like receptor 10 isoform b
NM_030956.4 NP_112218.2 toll-like receptor 10 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15728506 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15728506 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IPI
IPI: Inferred from physical interaction
23155421 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR10 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (72 - 128)

(372 - 387)

LRR_1

LRR_1: Leucine Rich Repeat (444 - 461)

TIR

TIR: TIR domain (636 - 773)

  • 0
  • 200
  • 400
  • 600
  • 811 a.a.
Protein Preferred Names Protein Names

toll-like receptor 10

TLR10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TLR10 Q9BXR5 TLR10 Homo sapiens Q9BXR5
ToxCat
23155421
Intra
TLR10 Q9BXR5 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
TLR10 Q9BXR5 ECEL1 Homo sapiens O95672
Anti Tag CoIP
33961781
Intra
TLR10 Q9BXR5 TLR10 Homo sapiens Q9BXR5
Anti Tag CoIP
15728506
Intra
TLR10 Q9BXR5 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
TLR10 Q9BXR5 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
TLR10 Q9BXR5 TLR2 Homo sapiens O60603
ToxCat
23155421
Intra
TLR10 Q9BXR5 CNPY3 Homo sapiens Q9BT09
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

TLR10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84770 TLR10 Antibody (YA4467) IHC-P, ICC/IF, ELISA Human
HY-P84770A TLR10 Antibody (YA4467)(PBS only) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Melioidosis

  • Melioidosis, Susceptibility To

  • Acute And Fulminating Melioidosis

  • Nightcliff Gardener'S Disease

  • Pseudoglanders

  • Subacute And Chronic Melioidosis

  • Burkholderia Pseudomallei Infection

  • Whitmore Disease

  • Whitmore'S Disease

  • B Pseudomallei Infection

  • Epizootic Lymphangitis

  • Infection Due To Burkholderia Pseudomallei

  • Infection Due To Burkholderia Pseudomallei Nos

  • Infection Due To Malleomyces Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei Nos

  • Infection Due To Whitmore Bacillus

  • Stanton Disease
Q Fever

  • Infection Due To Coxiella Burnetii

  • Quadrilateral Fever

  • Query Fever

  • Nine Mile Fever

  • Coxiella Burnetii Fever

  • Q Fever Pneumonia

  • Coxiellosis

  • Pneumonia In Q Fever

  • Australian Q Fever

  • Balkan Grippe
Tonsillitis

  • Chronic Tonsillitis

  • Throat Infection - Tonsillitis
Aspergillosis

  • Aspergillosis, Susceptibility To

  • Infection Due To Aspergillus

  • Aspergilloma

  • Aspergillus Nodule

  • Simple Aspergilloma

  • Aspergillus

  • Aspergillus Flavus Infection

  • Aspergillus Fumigatus Infection

  • Aspergillus Infection

  • Infection By Aspergillus Fumigatus

  • Intracavitary Aspergillus Fungus Ball

  • Aspergillus Terreus
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Superficial Basal Cell Carcinoma

  • Multifocal Superficial Basal Cell Carcinoma

  • Multicentric Basal Cell Carcinoma

  • Superficial Multicentric Basal-Cell Carcinoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14579 TLR10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174527 Human TLR10 mRNA / Unkown
HY-RS25530 Tlr10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TLR10 VGNC VGNC:66217
Canis familiaris TLR10 VGNC VGNC:53248
Macaca mulatta TLR10 VGNC VGNC:78392
Rattus norvegicus TLR10 RGD RGD:1311569
Bos taurus TLR10 VGNC VGNC:50019
Others TLR10 NCBI