TLR10 - toll like receptor 10 Gene

Homo sapiens

Also known as CD290

Gene ID: 81793 | Gene type: protein coding

About TLR10

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:38,772,238-38,782,990 (from NCBI)

This gene has 8 transcripts (splice variants), 56 orthologues and 22 paralogues. Biased expression in lymph node (RPKM 20.4), spleen (RPKM 11.7) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

TLR10 Products(5)

mRNA	Protein	Name
NM_001017388.3	NP_001017388.1	toll-like receptor 10 isoform a
NM_001195106.2	NP_001182035.1	toll-like receptor 10 isoform a
NM_001195107.2	NP_001182036.1	toll-like receptor 10 isoform a
NM_001195108.2	NP_001182037.1	toll-like receptor 10 isoform b
NM_030956.4	NP_112218.2	toll-like receptor 10 isoform a

TLR10 Protein Structure

LRR_8

LRR_1

TIR

0
200
400
600
811 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 10

Related Diseases

Diseases

Alias

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Q Fever

Infection Due To Coxiella Burnetii	Quadrilateral Fever
Query Fever	Nine Mile Fever
Coxiella Burnetii Fever	Q Fever Pneumonia
Coxiellosis	Pneumonia In Q Fever
Australian Q Fever	Balkan Grippe

Tonsillitis

Chronic Tonsillitis

Throat Infection - Tonsillitis

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma	Multicentric Basal Cell Carcinoma
Superficial Multicentric Basal-Cell Carcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14579	TLR10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TLR10	VGNC	VGNC:66217
Canis familiaris	TLR10	VGNC	VGNC:53248
Macaca mulatta	TLR10	VGNC	VGNC:78392
Rattus norvegicus	TLR10	RGD	RGD:1311569
Bos taurus	TLR10	VGNC	VGNC:50019

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