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Cat. No.: HY-116696

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GSK3-IN-11

GSK3-IN-11 is a Glycogen Synthase Kinase-3 (GSK-3) inhibitor with an IC₅₀ of 5010 nM.

For research use only. We do not sell to patients.

CAS No.: 681432-07-5
Formula: C₂₅H₂₀N₆O₃
Molecular Weight:452.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSK3-IN-11 Chemical Structure

CAS No.: 681432-07-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

GSK3-IN-11 is a Glycogen Synthase Kinase-3 (GSK-3) inhibitor with an IC₅₀ of 5010 nM^[1].

IC₅₀ & Target^[1]

GSK-3

5010 nM (IC₅₀)

All GSK-3 Isoforms :

In Vitro

GSK3-IN-11 (Compound 117) inhibits GSK-3 with an experimental IC₅₀ of 5010 nM (pIC₅₀ = 5.300)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 681432-07-5
Molecular Weight 452.47
Formula C₂₅H₂₀N₆O₃
SMILES

N1=CC=C(N=C1NC2=CC=C3OCCOC3=C2)C=4C(=NN5N=CC=CC45)C6=CC=C(OC)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Katritzky AR, et al. QSAR modeling of the inhibition of glycogen synthase kinase-3. Bioorg Med Chem. 2006 Jul 15;14(14):4987-5002. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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GSK3-IN-11

All GSK-3 Isoforms