3-Hydroxykynurenine
Based on 2 publication(s) in Google Scholar
3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis.
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- 純度: 99.93%
- CAS 番号: 484-78-6
- 分子式: C10H12N2O4
- 分子量:224.21
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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MedChemExpress（MCE）の使用を引用している文献 3-Hydroxykynurenine
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1].
3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1].
3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1].
3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM[2].
3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CD3/CD28 bead-stimulated CD4+ T cells
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Concentration:0, 20, 40, 60, 80, and 100 μM
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Incubation Time:72 hours
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Result:Significantly inhibited CD4+ T-cell proliferation in a dose-dependent manner with an IC50 of approximately 70 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (H2d) mice[2]
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Dosage:560 mg/kg
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Administration:IP injection
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Result:There was significant prolongation of graft survival in all treatment groups in comparison to the controls.
化学情報
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CAS 番号 484-78-6
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性状 Solid
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分子量 224.21
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分子式 C10H12N2O4
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Color Light yellow to yellow
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SMILES
O=C(O)C(N)CC(C1=CC=CC(O)=C1N)=O
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別名
3-Hydroxy-DL-kynurenine; 3-ヒドロキシ-DL-キヌレニン
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Mechanism of Trichinella spiralis-mediated CD4+ T cell functional imbalance via IDO-dependent tryptophan metabolism. [Abstract]2026 May 15:177:116517. PMID: 41864014 -
Psychoneuroendocrinology
Peripheral cytokine dysregulation, microglial dysfunction in adolescent major depressive disorder: Neuroimmune crosstalk implications. [Abstract]2025 Oct 17:183:107656. PMID: 41138684
3-Hydroxykynurenine purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2025 Oct 17:183:107656. [Abstract]
After HMC3 cells were treated with indicated concentrations of 3-Hydroxykynurenine (3-HK, 10-160 μM), morphological changes were observed using an optical microscope.
3-Hydroxykynurenine purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2025 Oct 17:183:107656. [Abstract]
After HMC3 cells were treated with indicated concentrations of 3-Hydroxykynurenine (3-HK, 10-160 μM), Annexin V/PI staining was performed followed by flow cytometric analysis.
3-Hydroxykynurenine purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2025 Oct 17:183:107656. [Abstract]
After HMC3 cells were treated with indicated concentrations of 3-Hydroxykynurenine (3-HK, 10-160 μM), cell viability was analyzed by CCK-8 staining.
3-Hydroxykynurenine purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2025 Oct 17:183:107656. [Abstract]
After HMC3 cells were treated with indicated concentrations of 3-Hydroxykynurenine (3-HK, 10-160 μM), Sub-G1 analysis was performed by flow cytometry.
3-Hydroxykynurenine purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2025 Oct 17:183:107656. [Abstract]
After HMC3 cells were treated with indicated concentrations of 3-Hydroxykynurenine (3-HK, 40-160 μM), immunoblotting was performed for the indicated antigens.
3-Hydroxykynurenine purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2025 Oct 17:183:107656. [Abstract]
After HMC3 cells were treated with indicated concentrations of 3-Hydroxykynurenine (3-HK, 40-160 μM), culture supernatants were collected and the release of LDH and IL-1β was assessed.
溶剤 & 溶解度
1M HCl : 33.33 mg/mL (148.66 mM; ultrasonic and adjust pH to 1 with HCl)
DMSO : 1 mg/mL (4.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
[1]. S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70(1):299-307. [Content Brief]
[2]. Sarah S Zaher,et al. 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2011 Apr 22;52(5):2640-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1M HCl | 1 mM | 4.4601 mL | 22.3005 mL | 44.6010 mL | 111.5026 mL |
| 1M HCl | 5 mM | 0.8920 mL | 4.4601 mL | 8.9202 mL | 22.3005 mL |
| 10 mM | 0.4460 mL | 2.2301 mL | 4.4601 mL | 11.1503 mL | |
| 15 mM | 0.2973 mL | 1.4867 mL | 2.9734 mL | 7.4335 mL | |
| 20 mM | 0.2230 mL | 1.1150 mL | 2.2301 mL | 5.5751 mL | |
| 25 mM | 0.1784 mL | 0.8920 mL | 1.7840 mL | 4.4601 mL | |
| 30 mM | 0.1487 mL | 0.7434 mL | 1.4867 mL | 3.7168 mL | |
| 40 mM | 0.1115 mL | 0.5575 mL | 1.1150 mL | 2.7876 mL | |
| 50 mM | 0.0892 mL | 0.4460 mL | 0.8920 mL | 2.2301 mL | |
| 60 mM | 0.0743 mL | 0.3717 mL | 0.7434 mL | 1.8584 mL | |
| 80 mM | 0.0558 mL | 0.2788 mL | 0.5575 mL | 1.3938 mL | |
| 100 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1150 mL |
3-Hydroxykynurenine 関連分類
HY-113294 関連分類
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