3-Hydroxykynurenine-¹³C₂,¹⁵N hydrochloride  (Synonyms: 3-Hydroxy-DL-kynurenine-13C2,15N hydrochloride)

3-Hydroxykynurenine-¹³C₂,¹⁵N (3-Hydroxy-DL-kynurenine-¹³C₂,¹⁵N) hydrochloride is the ¹³C and ¹⁵N labeled 3-Hydroxykynurenine hydrochloride (HY-113294)^[1]. 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis^[2].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₈¹³C₂H₁₂N¹⁵NO₄.xHCl

484-78-6

Solid

Light green to green

OC1=CC=CC(C(C[13CH]([15NH2])[13C](O)=O)=O)=C1N.[xHCl]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70(1):299-307.  [Content Brief]