5-Formyl-dCTP lithium
5-Formyl-dCTP (5-Formyl-deoxycytidine) lithium is a DCTPP1 substrate. 5-Formyl-dCTP lithium acts as a mutagen/epigenetic disruptor via DNA polymerase incorporation, mutagenic mispairings, and disturbed epigenetic programming. 5-Formyl-dCTP lithium can be used for research on genotoxicity.
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- CAS 番号: 2409156-19-8
- 分子式: C10H12Li4N3O14P3
- 分子量:518.90
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
5-Formyl-dCTP lithium exhibits enriched, specific binding to Con A (Kd,eff = 20 nM) with minimal binding to PSA (Kd,eff > 1 μM) after three rounds of two-color click-PD screening[1].
5-Formyl-dCTP lithium (10-250 μM) is hydrolysed by purified recombinant human DCTPP1 with high efficiency, exhibiting a Km of 9.2 μM, the lowest substrate affinity reported for the enzyme, and a specificity constant of 322,000/M·s[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2409156-19-8
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分子量 518.90
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分子式 C10H12Li4N3O14P3
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SMILES
O=CC1=CN([C@@H](C[C@@H]2O)O[C@@H]2COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)C(N=C1N)=O
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別名
5-Formyl-deoxycytidine lithium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gordon CKL, et al. Click-Particle Display for Base-Modified Aptamer Discovery. ACS Chem Biol. 2019;14(12):2652-2662. [Content Brief]
[2]. Requena CE, et al. The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells. Biochem J. 2014;459(1):171-180. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
5-Formyl-dCTP lithium 関連分類
HY-160596 関連分類
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