Bekanamycin
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Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 4696-76-8
- 分子式: C18H37N5O10
- 分子量:483.51
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
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Aminoglycoside |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>500 μg/mL
Compound: Kanamycin
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Cytotoxicity against HEK293 cells measured after 24 hrs by MTT assay
Cytotoxicity against HEK293 cells measured after 24 hrs by MTT assay
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[PMID: 31390524] |
| NIH3T3 | IC50 |
139.6 μM
Compound: Kanamycin B
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Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
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[PMID: 24332628] |
| NIH3T3 | IC50 |
139.6 μM
Compound: Kanamycin B
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Cytotoxic activity against mouse NIH/3T3 cells after 24 hrs by MTT assay
Cytotoxic activity against mouse NIH/3T3 cells after 24 hrs by MTT assay
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10.1039/C6MD00263C |
Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus[2].
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 4696-76-8
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性状 Solid
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分子量 483.51
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分子式 C18H37N5O10
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Color White to off-white
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SMILES
O[C@H]1[C@](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@@]3([H])O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)([H])O[C@H](CO)[C@@H](O)[C@@H]1N
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別名
Kanamycin B
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Structure Classification
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Initial Source
Streptomyces kanamyceticus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 100 mg/mL (206.82 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
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- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gao W, et al. Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus viametabolic engineering. PLoS One. 2017 Jul 28;12(7):e0181971. [Content Brief]
[2]. Fosso MY, et al. Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. J Med Chem. 2015 Dec 10;58(23):9124-32. [Content Brief]
[3]. Uchiyama T, et al. Presynaptic effects of bekanamycin at the frog neuromuscular junction. Reversibility by calcium and aminopyridines. Eur J Pharmacol. 1981 Jul 10;72(4):271-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0682 mL | 10.3410 mL | 20.6821 mL | 51.7052 mL |
| 5 mM | 0.4136 mL | 2.0682 mL | 4.1364 mL | 10.3410 mL | |
| 10 mM | 0.2068 mL | 1.0341 mL | 2.0682 mL | 5.1705 mL | |
| 15 mM | 0.1379 mL | 0.6894 mL | 1.3788 mL | 3.4470 mL | |
| 20 mM | 0.1034 mL | 0.5171 mL | 1.0341 mL | 2.5853 mL | |
| 25 mM | 0.0827 mL | 0.4136 mL | 0.8273 mL | 2.0682 mL | |
| 30 mM | 0.0689 mL | 0.3447 mL | 0.6894 mL | 1.7235 mL | |
| 40 mM | 0.0517 mL | 0.2585 mL | 0.5171 mL | 1.2926 mL | |
| 50 mM | 0.0414 mL | 0.2068 mL | 0.4136 mL | 1.0341 mL | |
| 60 mM | 0.0345 mL | 0.1724 mL | 0.3447 mL | 0.8618 mL | |
| 80 mM | 0.0259 mL | 0.1293 mL | 0.2585 mL | 0.6463 mL | |
| 100 mM | 0.0207 mL | 0.1034 mL | 0.2068 mL | 0.5171 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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