Antiproliferative agent-3
Antiproliferative agent-3 is an antiproliferative agent. Antiproliferative agent-3 exhibits anticancer activity against a variety of cancers, including estrogen receptor-positive breast cancer. Antiproliferative agent-3 shows no toxicity to wild-type zebrafish embryos. Antiproliferative agent-3 can be used in the research of chronic myeloid leukemia, promyelocytic leukemia, Burkitt's lymphoma, estrogen receptor-positive mammary adenocarcinoma, cervical cancer, and lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C11H12N2O5S
- 分子量:284.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Antiproliferative agent-3 (Compound 4) (72 h) potently inhibits the growth of multiple human tumour cell lines, with exceptional activity against MCF-7 cells (IC50 = 0.00019 μM), and shows no toxicity to MRC-5 normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type[1]
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Dosage:1 µM, 2.5 µM, 5 µM, 10 µM, 25 µM, 50 µM, 100 µM, 125 µM
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Administration:in embryo water; continuous; 6 hpf to 120 hpf
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Result:Allowed all embryos to survive at all tested concentrations up to 125 µM, with no teratogenic malformations.
Resulted in an embryo heartbeat rate of 154 beats per minute at 125 µM, compared to 158 beats per minute in the control group, with no pericardial edema observed.
Determined a lethal concentration 50 (LC50) to be >125 µM.
化学情報
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分子量 284.29
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分子式 C11H12N2O5S
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SMILES
NC(C1=CSC(C[C@H]2O[C@@H]3CC(O[C@@H]3[C@H]2O)=O)=N1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antiproliferative agent-3 関連分類
HY-145866 関連分類
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- Antiproliferative agent-3
- Antiproliferative agent3
- Antiproliferative agent 3
- Drug Intermediate
- T cell leukaemia
- lung carcinoma
- oestrogen receptor positive breast adenocarcinoma
- chronic myeloid leukaemia
- promyelocytic leukaemia
- estrogen receptor positive breast adenocarcinoma cells
- MCF-7 cells
- cervix carcinoma
- zebrafish models
- Burkitt’s lymphoma
- Inhibitor
- inhibitor
- inhibit