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BAY-3827

18 Cited Publications
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Based on 18 publication(s) in Google Scholar

BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines.

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  • 純度: 99.72%
  • CAS 番号: 2377576-35-5
  • 分子式: C27H25FN6O
  • 分子量:468.53
  • 保管条件:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • BAY-3827 Chemical Structure
    BAY-3827 構造式
  • Experimental Validation Results for BAY-3827
  • Experimental Validation Results for BAY-3827
  • Experimental Validation Results for BAY-3827
  • Experimental Validation Results for BAY-3827
  • Experimental Validation Results for BAY-3827
CAS 番号: 2377576-35-5
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  • BAY-3827 Chemical Structure
    BAY-3827 Chemical Structure
    1/16
  • 1/16

    BAY-3827 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Dec 15.

    Customer Validation
     BAY-3827 at 10 mg/kg for a duration of 4 weeks. Distinctive micro-CT visuals showcasing both longitudinal and cross-sectional views of the distal femur segments.

  • 1/16

    BAY-3827 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Dec 15.

    Customer Validation
     BAY-3827 was administered at 10 mg/kg for a duration of 4 weeks. Representative images of hematoxylin and eosin (H&E) staining and Masson's staining of the metaphyseal tissue sections of the thigh were presented.

  • 1/16

    BAY-3827 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Dec 22. [Abstract]

    Customer Validation
     ELISA quantification of IL-1β in BMDM supernatants following LPS + nigericin stimulation with or without Api, the AMPK agonist AICAR, or the AMPK inhibitor BAY-3827 (500 nM) was performed.

  • 1/16

    BAY-3827 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Oct 16;26(20):10098. [Abstract]

    Customer Validation
     HCFs were incubated with the AMPK inhibitor BAY-3827 (500 nM) for 1 h prior to stimulation with DMSO (vehicle) or indicated concentrations of SGLT2i for 3 h.

  • 1/16

    BAY-3827 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Oct 16;26(20):10098. [Abstract]

    Customer Validation
     HCFs were incubated with the AMPK inhibitor BAY-3827 (500 nM) for 1 h prior to stimulation with DMSO (vehicle) or indicated concentrations of SGLT2i for 72 h.

  • BAY-3827